Results 201 to 210 of about 110,287 (267)
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Choline acetyltransferase in cochlear root neurons
Hearing Research, 1993Cochlear root neurons are a distinct group of cells located in the auditory nerve root in small rodents. Their transmitter is still unknown. Some of our preparations showed immunoreactivity of somata of cochlear root neurons with both polyclonal and monoclonal antibodies against choline acetyltransferase (ChAT) which, despite their very weak ...
Donald A. Godfrey, Weiping Yao
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The acetylation of hemicholinium-3 by choline acetyltransferase
Biochemical Pharmacology, 1976Abstract The acetylation of hemicholinium-3 (HC-3) by choline acetyltransferase (ChAc) from a rat brain homogenate has been investigated using several different methods to recover the acetylated product. These methods are based on precipitation by ammonium reineckate, binding to an ion-exchange column (Amberlite CG-50), extraction with sodium ...
Brian A. Hemsworth, David Bradshaw
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Amines and choline acetyltransferase in rat intestine
Neurochemistry International, 1983A biochemical study of the endogenous levels of serotonin (5-HT), noradrenaline (NA) and the activity of choline acetyltransferase (CAT) was carried out in the intestinal tract of the rat. High levels of 5-HT and NA were detected in the caecum and the colon. These anatomical regions also presented the highest activity of CAT.
Maxime Faudon +2 more
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Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
Science, 1985Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified ...
William C. Mobley +4 more
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Choline acetyltransferase: Purification and characterization
Journal of Neuroscience Research, 1980AbstractCholine acetyltransferase catalyzes the synthesis of the neurotransmitter acetylcholine and is the specific enzyme marker for cholinergic neurons. This review summarizes and discusses different purification procedures, as well as the characteristics of this important enzyme.
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Detection of choline‐acetyltransferase activity in lymphocytes
Journal of Neuroscience Research, 1993AbstractThe cholinergic system takes part in the immune‐neuroendocrine interation. Lymphocytes have been found to express muscarinic and nicotinic cholinergic receptors, as well as acetylcholine‐esterase on their surface, and cholinergic agents modulate immune functions in vitro and in vivo.
K. Schauenstein, I. Rinner
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Localization of choline acetyltransferase at neuromuscular junctions
Muscle & Nerve, 1981AbstractCholine acetyltransferase (ChAc) was localized at the neuromuscular junctions of rabbit diaphragm with immunohistochemical staining, which produced a brown color, in combination with histochemical staining for cholinesterase, which produced a blue color, in the same section.
K. ‐S. Karen Kan, Li‐Pen Chao
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Choline Acetyltransferase Activity in Omental Tissue
British Journal of Neurosurgery, 1987Choline acetyltransferase (ChAT), the enzyme responsible for the formation of ACh from choline and acetyl-coenzyme A, is a marker of cholinergic function and is significantly depressed in the brains of Alzheimer patients. It has been shown that omental tissue contains several neuroactive substances and causes revascularization when placed upon the ...
Gordon C. Siek +2 more
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An endogeneous inhibitory factor for choline acetyltransferase
Brain Research, 1983Chromatography of partially purified choline acetyltransferase (CAT) over carboxymethyl cellulose may result in the loss of up to 95% of the enzyme activity. This loss of activity can be prevented by running the chromatographs at low protein concentration with a large gradient volume suggesting that interactions between CAT and other endogenous ...
Costantino Cozzari, Boyd K. Hartman
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Substrate binding and catalytic mechanism of human choline acetyltransferase.
Biochemistry, 2006Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine from choline and acetyl-CoA, and its presence is a defining feature of cholinergic neurons.
Ae-Ri Kim, R. Rylett, B. Shilton
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