Results 251 to 260 of about 129,516 (303)

Measurement and activation of choline acetyltransferase

Biochemical Pharmacology, 1975
Abstract A method for the radiometric assay of choline acetyltransferase, depending for the separation of the product [1- 14 C]acetylcholine, from the substrate, [1- 14 C]acetyl-CoA, on elution through an anion exchange resin has been modified so as to increase its sensitivity, reduce the blanks and improve the accuracy.
C, Hebb, S P, Mann, J, Mead
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[249] Choline acetyltransferase

1971
Publisher Summary This chapter discusses the methods of preparation of Choline Acetyltransferase. Rates of synthesis of acetylcholine are linear with choline acetyltransferase concentration if all other components of the reaction mixture are added in excess.
openaire   +1 more source

SUBUNITS OF CHOLINE ACETYLTRANSFERASE (EC 2.3.1.6)

Journal of Neurochemistry, 1975
Abstract— The molecular weight of choline acetyltransferase is determined to be approx 87,000‐89,000 daltons. There are 808 amino acid residues per molecule of the enzyme with a calculated mol. wt of 89,300. Peptides of ChAc were studied after tryptic digestion, cyanogen bromide and BNPS‐skatole cleavages.
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Choline acetyltransferase activity in murine thymus

Journal of Neuroscience Research, 1992
AbstractMurine thymus has been demonstrated to contain both cholinergic receptors and acetylcholinesterase activity. In the present study we have investigated the presence of the enzyme choline acetyltransferase in this organ, which is responsible for the synthesis of acetylcholine.
M A, Tria, G, Vantini, M G, Fiori, A, Rossi   +3 more
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Choline Acetyltransferase and Neuronal Maturation

1973
Publisher Summary This chapter mentions the development of choline acetyltransferase in a restricted segment of the developing nervous system in relation to other parameters of neuronal maturation. A number of studies have indicated that the use of a small segment of the developing neural axis can reveal pronounced changes in the biochemical ...
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Choline acetyltransferase in the equine spleen

General Pharmacology: The Vascular System, 1979
Abstract 1. 1. Choline acetyltransferase (ChAc) has been investigated in the spleens of the horse ( Equus cahallus ) and donkey ( Equus asinus ) and found to be present in amounts ranging from 0.34–6.86 μmol of ACh synthesized g −1 hr −1 . Spleens of other ungulates investigated contained much less than this. 2. 2. ACh content of the spleens
L G, Stephens-Newsham, C, Hebb, S P, Mann, H, Banns   +3 more
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Inhibition of choline acetyltransferase by quaternary ammonium analogues of choline

Biochemical Pharmacology, 1975
Abstract The effects of the choline analogues hemicholinium-3, triethylcholine, tetraethylammonium and acetylcholine on the synthesis of ACh by choline acetyltransferase have been studied in vitro. Hemicholinium-3 is shown to be an inhibitor of choline acetyltransferase with a Ki of 2·5 mM. HC-3, TEA and ACh are competitive with choline.
S P, Mann, C, Hebb
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A rapid radiochemical method for the determination of choline acetyltransferase

Journal of Neurochemistry, 1975
F. Fonnum
semanticscholar   +1 more source

Choline acetyltransferase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
H.L. White, C.J. Cavallito
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Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase

Neurobiology of Aging, 2013
D. Park, Yun-Hui Yang, D. K. Bae, Sun Hee Cho Lee, Goeun Yang, Jangbeen Kyung, Dajeong Kim, E. Choi, Seong Won Lee, Gon-Hyung Kim, J. Hong, Kyung-Chul Choi, Hong J Lee, Seung U. Kim, Yun-Bae Kim   +14 more
semanticscholar   +1 more source