Results 31 to 40 of about 17,945 (232)

Inhibition of choline acetyltransferase by monoclonal antibodies [PDF]

The Journal of Neuroscience, 1985
Four monoclonal antibodies were obtained to rat brain choline acetyltransferase (CAT). The enzyme was purified 95,000-fold from rat brain by precipitation with acetic acid at pH 4.5, fractionation with 40 to 60% (NH4)2SO4, CM-Sephadex chromatography, and affinity column chromatography on agarose-hexane-coenzyme A.
M Nirenberg, WL Strauss
openaire   +3 more sources

Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect

Acta Cirúrgica Brasileira, 2023
Purpose: Intravenous anesthetics have excellent analgesic activity without inducing the side effect in the respiratory system. The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against ...
Yi Gong, Peipei Kang, Junhui Wang, Yan Chen, Zhongliang Wei   +4 more
doaj   +1 more source

CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer’s disease in the Czech population

Journal of Biomedical Science, 2018
Background Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with Alzheimer’s disease.
Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar, Omar Šerý   +8 more
doaj   +1 more source

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus

Frontiers in Neural Circuits, 2020
The inferior colliculus processes nearly all ascending auditory information. Most collicular cells respond to sound, and for a majority of these cells, the responses can be modulated by acetylcholine (ACh). The cholinergic effects are varied and, for the
William A. Noftz, William A. Noftz, Nichole L. Beebe, Jeffrey G. Mellott, Brett R. Schofield, Brett R. Schofield   +5 more
doaj   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +15 more
wiley   +1 more source

Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice

Journal of Ginseng Research, 2017
Background: Black ginseng has a more potent biological activity than non-steamed ginseng. We investigated the effects of long-term intake of dietary black ginseng extract (BG) on antioxidant activity in aged mice.
Mi Ra Lee, Jin Yeul Ma, Chang Keun Sung
doaj   +1 more source

Sensory and Autonomic Fibers in Anterior Ethmoid, Posterior Nasal, Posterolateral Nasal Nerves. [PDF]

Laryngoscope
All cadaveric anterior ethmoid, posterior, and posterolateral nasal nerves contained roughly equivalent proportions of sensory, parasympathetic, and sympathetic nerve fiber markers. Neurokinin A was the only neuropeptide with consistently greater percent areas across the different nasal nerves.
Craig JR, Mason W, Laumet G, Alkhoory W, Hensley MD, Holleman D, Hason N.   +6 more
europepmc   +2 more sources

Choline Acetyltransferase

Journal of Biological Chemistry, 1974
Abstract Choline acetyltransferase (EC 2.3.1.6) catalyzes the reversible transfer of the acetyl group from acetyl coenzyme A to choline. Previous studies are consistent with the idea that an active site sulfhydryl group reacts with acetyl coenzyme A to form an acetyl-thioenzyme intermediate and coenzyme A (Roskoski, R., Jr. (1973) Biochemistry 12, 3709)
openaire   +3 more sources

Axonal profiling of the common fibular nerve and its branches: Their functional composition and clinical implications

Clinical Anatomy, EarlyView.
Abstract The articular branch (Arb) from the common fibular nerve (CFN) plays a pivotal role in procedures such as genicular nerve blocks since it extensively innervates the anterolateral knee joint. It remains unclear whether the Arb can be classified as purely sensory, and understanding its axonal composition is critical to prevent muscle weakness ...
Taeyeon Kim, Tae‐Hyeon Cho, Shin Hyung Kim, Hun‐Mu Yang   +3 more
wiley   +1 more source