Results 41 to 50 of about 129,516 (303)

Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers*

Journal of Biological Chemistry, 2012
Background: Cholinergic dysfunction is an early feature of Alzheimer disease (AD). Results: Soluble oligomers of the amyloid-β peptide (Aβ) bind to cholinergic neurons and inhibit choline acetyltransferase (ChAT) activity before any cell death or lesion.
N. Nunes-Tavares, L. E. Santos, B. Stutz, Jordano Brito‐Moreira, W. Klein, S. Ferreira, F. D. de Mello   +6 more
semanticscholar   +1 more source

Immunolocalization of choline acetyltransferase of common type in the central brain mass of Octopus vulgaris

European Journal of Histochemistry, 2012
Acetylcholine, the first neurotransmitter to be identified in the vertebrate frog, is widely distributed among the animal kingdom. The presence of a large amount of acetylcholine in the nervous system of cephalopods is well known from several biochemical
A. Casini, R. Vaccaro, L. D'Este, Y. Sakaue, J.P. Bellier, H. Kimura, T.G. Renda   +6 more
doaj   +1 more source

Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]

, 2001
DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof, Frohman, Michael A, Zhao, Di   +2 more
core   +3 more sources

Choline acetyltransferase-containing neurons in the human parietal neocortex

European Journal of Histochemistry, 2009
A number of immunocytochemical studies have indicated the presence of cholinergic neurons in the cerebral cortex of various species of mammals. Whether such cholinergic neurons in the human cerebral cortex are exclusively of subcortical origin is still ...
V Benagiano, D Virgintino, P Flace, F Girolamo, M Errede, L Roncali   +5 more
doaj   +1 more source

Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease [PDF]

, 1993
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects.
Jenner, P., Lange, Klaus W., Marsden, C. D., Wells, F. R.   +3 more
core   +1 more source

Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model

Neural Regeneration Research, 2017
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction (MI). Increasing evidence indicates that neuregulin-1 (NRG-1) improves cardiac function following heart failure.
Xin Lai, Liang Zhong, Hai-xia Fu, Song Dang, Xin Wang, Ning Zhang, Gao-ke Feng, Zi-qiang Liu, Xi Wang, Long Wang   +9 more
doaj   +1 more source

ACETYLCHOLINE AND ITS SYNTHESIZING ENZYME CHOLINE ACETYLTRANSPHERASE IN THE ENTERIC NERVOUS SYSTEM [PDF]

Journal of IMAB, 2022
The enteric nervous system is the largest and most complex division of the peripheral nervous system. Located in the wall of the gastrointestinal tract, it is a regulatory and coordination unit of the nervous system.
Desislava M. Marinova, Miroslav L. Dobrev, Tihomir R. Rashev, Iskren K. Gerasimov, Vladislav Nankov, Stefan V. Trifonov   +5 more
doaj   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Localization of α-synuclein in teleost central nervous system: immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp, Cyprinus carpio [PDF]

, 2015
Alpha synuclein (α-syn) is a 140 amino acid vertebrate-specific protein, highly expressed in the human nervous system and abnormally accumulated in Parkinson's disease and other neurodegenerative disorders, known as synucleinopathies.
CASINI, Arianna, CIONI, Carla, L. D’Este, S. Yu, TONI, MATTIA, VACCARO, Rosa, VIVACQUA, GIORGIO   +6 more
core   +1 more source

Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus

Frontiers in Neural Circuits, 2020
The inferior colliculus processes nearly all ascending auditory information. Most collicular cells respond to sound, and for a majority of these cells, the responses can be modulated by acetylcholine (ACh). The cholinergic effects are varied and, for the
William A. Noftz, William A. Noftz, Nichole L. Beebe, Jeffrey G. Mellott, Brett R. Schofield, Brett R. Schofield   +5 more
doaj   +1 more source