Results 61 to 70 of about 17,945 (232)
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology &Motility, EarlyView.Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2015 Purpose. Ginkgo extract EGb 761 and cholinesterase inhibitors have been shown to be effective in the treatment of dementia patients. In addition to neuroprotective effects, Ginkgo extract EGb 761 has been reported to elevate brain levels of certain ...
Christoph Stein +3 more
doaj +1 more source
Neurogastroenterology &Motility, EarlyView.In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.This study used a stereoscopic imaging method that combines tissue clearance, immunohistochemistry, and confocal imaging techniques to construct a quantifiable three‐dimensional view of the enteric nervous system, accurately evaluating changes in the enteric nervous system of patients with slow transit constipation.
Gaoyuan Tian +7 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Tryptophan decarboxylase (TDC), the rate‐limiting enzyme of tryptophan metabolism in plants, is essential for the production of a series of bioactive molecules, such as serotonin, melatonin and the plant hormone indole‐3‐acetic acid and therefore plays crucial roles in various aspects of growth and development.
Haili Zhang +13 more
wiley +1 more source
Optogenetic methods to stimulate gamma motor neuron axons ex vivo
Experimental Physiology, EarlyView.Abstract It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to
Apoorva Karekal +7 more
wiley +1 more source
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise
The Journal of Physiology, EarlyView.Abstract figure legend This study unveiled the essential role of the orexinergic nervous system in the central circuitry that transmits central command signals for locomotor exercise. We observed the excitation of orexinergic neurons by voluntary locomotor exercise in rats.
Emi Narai +7 more
wiley +1 more source
The mysterious middlemen making your vision pop: understanding the function of amacrine cells
The Journal of Physiology, EarlyView.Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia +3 more
wiley +1 more source