Results 81 to 90 of about 129,516 (303)

Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3

Neurosciences research, 2008
Mutations in the superoxide dismutase 1 (sod1) gene cause familial amyotrophic lateral sclerosis (FALS), likely due to the toxic properties of misfolded mutant SOD1 protein.
M. Tateno, S. Kato, T. Sakurai, N. Nukina, R. Takahashi, T. Araki   +5 more
semanticscholar   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Organization of acetylcholine containing structures in the cranial motor nuclei of the rhombencephalon of the pig

Veterinární Medicína, 2007
We explored the immunoreactivity of choline acetyltransferase (ChAT) in the cranial nerve motor nuclei of the porcine rhombencephalon to reveal the cholinergic nature of these regions.
M. Zalecki, J. Calka, M. Lakomy
doaj   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [PDF]

, 2004
An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing.
Alvarado, JC, Delgado-Garcia, JM, Escudero, M, Marquez-Ruiz, J, Navarro-Lopez, J, Yajeya, J   +5 more
core   +5 more sources

Weak if any effect of estrogen on spatial memory in rats [PDF]

, 2002
In a number of species, males appear to have spatial abilities that are superior to those of females. The favored explanation for this cognitive difference is hormonal: higher testosterone levels in males than in females.
Farkas, Tamás, Kis, Zsolt, Németh, Hajnalka, Toldi, József, Tóth, Tünde, Varga, Hedvig   +5 more
core  

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, EarlyView.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source

Physiological functions of the cholinergic system in immune cells

Journal of Pharmacological Sciences, 2017
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase (ChAT), muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and ...
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]

, 2016
Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab, Antonioli, Luca, Ballabeni, Vigilio, Barocelli, Elisabetta, Bernardini, Nunzia, Blandini, Fabio, Blandizzi, Corrado, Cerri, Silvia, Colucci, ROCCHINA LUCIA, Fornai, Matteo, Ippolito, Chiara, Levandis, Giovanna, Pellegrini, Carolina, Segnani, Cristina, Vegezzi, Gaia   +14 more
core   +1 more source

Optimization of carbon and nitrogen utilization for enhanced photosynthesis, biomass and yield by coexpression of phosphoenolpyruvate carboxylase, aspartate aminotransferase and glutamine synthetase in Brassica juncea

Plant Biotechnology Journal, EarlyView.
Summary Coexpression of genes involved in carbon (C) and nitrogen (N) metabolism offers a promising avenue for improving crop yield. This study investigated the impact of coexpressing phosphoenolpyruvate carboxylase [ZmPEPC (P)], aspartate aminotransferase [GmAspAT (A)] and glutamine synthetase [NtGS (G)] in Brassica juncea to enhance plant yield ...
Mamta, Shiv Shanker Pandey, Anish Kaachra, Sachin Vashisath, Dinesh Kumar, Sanjay Kumar   +5 more
wiley   +1 more source