Results 131 to 140 of about 407,361 (290)
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source
Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery
Journal of Applied Polymer Science, Volume 143, Issue 40, October 20, 2026.Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale +3 more
wiley +1 more source
Chloride diffusion coeficient determination for specifications [PDF]
, 2005 Presented at the 6th International Congress on Global Construction, Dundee, ScotlandThe chloride diffusion resistance of reinforced concrete can have a major influence on durability.
Richardson, Mark G. +3 more
core
Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.ABSTRACT The sustainable advancement of aquaculture can be supported using functional feed ingredients with immunomodulatory activity. These studies evaluated the immunonutritional effects of dietary nucleotides (NU) and an olive bioactive extract (OE) in Pacific white shrimp (PWS), Penaeus vannamei. A 56‑day growth trial (n = 1000 PWS; PL42‐43; 1.23 ±
Sergi Segarra +5 more
wiley +1 more source
NMR in Biomedicine, Volume 39, Issue 10, October 2026.Hyperpolarized MRI is a promising clinical imaging modality in oncology, offering at least nine imaging contrasts obtainable with hyperpolarized [1‐13C]pyruvate as the injected agent, depending on the tissue and condition under investigation. Preclinical studies suggest that hyperpolarized MRI is warranted for detecting hepatocellular carcinoma within ...
Naama Lev‐Cohain +2 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim The myogenic response contributes considerably to blood flow autoregulation. Intracellular pH (pHi) has a substantial impact on small artery contractility. However, the role of putative pHi changes during myogenic constriction is unknown.
Ulrike Krien, Rudolf Schubert
wiley +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.ABSTRACT Background Skin aging, a key aspect of physiological decline, markedly affects appearance, making strategies to delay it vital for quality of life. Materials and Methods We applied network medicine analysis to screen herbal medicines from the TCMSP database, yielding an anti‐skin aging formula, ZiYuShuang (ZYS).
Yingpeng Tong +6 more
wiley +1 more source
Product inventory of the radiolysis of crystalline choline chloride [PDF]
The Journal of Physical Chemistry, 1967 Ackerman, Margaret, Lemmon, Richard M.
openaire +3 more sources