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Enhancement of salt intake by choline chloride
Physiology & Behavior, 1994The ingestion of salt (NaCl) in most societies far exceeds levels that are considered necessary and safe. To reduce salt intake, a rat model of salt taste acceptance was created to identify novel, more palatable salt substitutes/enhancers. To induce salt craving, male Sprague-Dawley rats were placed on a low-salt diet and injected weekly (SC) with ...
K W, Locke, S, Fielding
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The Gravimetric Determination of Choline Chloride and Choline Citrate
Journal of the American Pharmaceutical Association (Scientific ed.), 1950A gravimetric method for choline chloride and choline citrate utilizing ammonium reineckate as an analytical reagent. The choline salts are precipitated as choline reineckate in aqueous solution, filtered off, dried, and weighed. The data collected indicate that the method has a standard deviation of less than 0.2 per cent and that it is reliable and ...
R.E. Pankratz, F.J. Bandelin
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Hydration and ion association of aqueous choline chloride and chlorocholine chloride
Physical Chemistry Chemical Physics, 2019Choline hydration occurs predominantly via its hydroxyl group, and weak contact ion pair formation with Cl− is via the onium moiety.
Saadia Shaukat +5 more
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Effect of Calcium Chloride on Choline Esterase
Nature, 1953THE effect of salts on choline esterase activity has been studied by a number of investigators1–13. The results may be summarized as follows : (1) True choline esterase : salts with univalent or divalent cations inhibit at low concentrations of acetylcholine, whereas these salts activate at high concentrations of acetylcholine ; the optimum substrate ...
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Partial reversal of anticholinergic amnesia by choline chloride
Life Sciences, 1981Abstract Twenty young adult males were given tests of memory and mood after receiving choline chloride plus scopolamine, placebo plus scopolamine, and two placebos on separate days in randomized order. Scopolamine caused a marked impairment in performance on a verbal learning task.
R C, Mohs, K L, Davis, M I, Levy
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EEG effects of physostigmine and choline chloride in humans
Psychopharmacology, 1979Seventeen normal volunteers received either 0.5 mg, 1.5 mg, or 2.5 mg physostigmine i.v. in a placebo-drug-placebo single-blind design. EEG was recorded simultaneously and analyzed by computerized spectral analysis. Eleven healthy elderly volunteers (mean age = 69.1 years) with mild memory impairment were treated with placebo, followed by oral choline ...
A, Pfefferbaum +5 more
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Choline chloride treatment of memory deficits in the elderly
American Journal of Psychiatry, 1979Eight elderly patients with mild memory impairment were given choline chloride, a drug that increases brain acetylcholine concentrations. After 16 g/day of choline for 7 days, average memory performance was not different from performance during pre- and postcholine placebo treatment, although the patient with the poorest baseline performance improved ...
R C, Mohs +5 more
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Choline chloride in methylphenidate- and apomorphine-induced stereotypy
Life Sciences, 1978Abstract The effect of choline chloride on apomorphine- and methylphenidate-induced stereotypy in rats was tested. Subcutaneous administration of a single dose of choline chloride significantly reduced apomorphine-induced stereotypy. These results could not be attributed to a nonspecific obtunding effect of choline chloride, and indicate that choline
K L, Davis +3 more
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Sulfocholine (dimethylhydroxyethylsulfonium chloride) and choline metabolism in the rat
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969Abstract 1. 1. The metabolism of choline and sulfocholine (dimethylhydroxyethylsulfonium chloride) in the rat has been compared. 2. 2. Radioactivity from [Me-3H]sulfocholine is incorporated ten times faster into total liver phospholipids than from [35S]sulfocholine. There is no significant difference in the kidney or heart. 3. 3.
K S, Bjerve, J, Bremer
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Choline chloride in animal models of tardive dyskinesia
Life Sciences, 1978Abstract Rats treated chronically with haloperidol show evidence of supersensitive dopamine receptors by increased stereotypy when challenged with apomorphine. When such animals are treated acutely with choline chloride at the time of challenge, no changes in stereotypy were observed.
K L, Davis +3 more
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