Results 151 to 160 of about 1,083,054 (280)

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Genetic variants in acetylcholine processing and significant improvement with pyridostigmine in a patient with postural orthostatic tachycardia syndrome: a case report. [PDF]

Eur Heart J Case Rep
Stephenson KM, Foster B, Blitshteyn S.
europepmc   +1 more source

Immunohistochemical estimation of rat brain choline acetyltransferase related to learning and memory impairment induced by thiamine deficiency

, 1999
Osamu Nakagawasai, Soichi Hozumi, Takeshi Tadano, Koichi Tan‐No, Fukie Niijima, Kensuke Kisara   +5 more
openalex   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans

, 2005
Martin Kohlmeier, Kerry-Ann da Costa, Leslie M. Fischer, Steven H. Zeisel   +3 more
openalex   +2 more sources

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Effect of Dietary Supplementation with Folate on Choline Deficiency-Induced Hyperhomocysteinemia in Rats

, 2012
Ying Liu, Yiqun Liu, Tatsuya Morita, Makoto Mori, Kimio SUGIYAMA   +4 more
openalex   +2 more sources

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity. [PDF]

Nutrients
Chaturvedi D, Snigdha S, Grandner MA, Avena N, Patel P.   +4 more
europepmc   +1 more source

Erratum: Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources. [PDF]

Lab Anim Res, 2017
Kim SH, Lim Y, Park JB, Kwak JH, Kim KJ, Kim JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS.   +10 more
europepmc   +1 more source