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Hypertension produced by choline deficiency in rats
Pathology, 1970 Choline deficiency has been produced in young rats and some factors which affect the resulting hypertension have been studied. A micro-sphygmomanometric apparatus was devised to measure blood pressures which were found to rise after 7-10 days on the choline deficient diet to values 25-35 mm. Hg. higher than those of supplemented rats.
Kratzing, C. C. +2 more
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Kidney function during choline deficiency
Pathology, 1972 The relationship between kidney damage and hypertension caused by choline deficiency was studied in young male rats. Excretion of a test load of NaCI solution was used as a test of kidney function and it was found that the proportion of Na+ of the test load excreted in 4 hours decreased significantly as choline deficiency progressed.
Kratzing C.C. +3 more
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Lipid Peroxidation in Choline-Methionine Deficiency
Free Radical Research Communications, 1987A deficiency of choline and methionine is hepatocarcinogenic and is associated with an apparent increase in lipid peroxidation. In this study the susceptibility of microsomes and nuclei to ferritin-dependent lipid peroxidation is examined together with the status of the peroxidation-protective systems.
B Ketterer, D J Meyer, Brian Ketterer
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Choline Deficiency Increases Lymphocyte Apoptosis and DNA Damage in Humans. [PDF]
American Journal of Clinical Nutrition, 2006 Background: Whereas deficiency of the essential nutrient choline is associated with DNA damage and apoptosis in cell and rodent mod-els, it has not been shown in humans. Objective: The objective was to ascertain whether lymphocytes from choline-deficient
Steven H Zeisel +2 more
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Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency [PDF]
Gastroenterology, 2011 Background & Aims: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood.
Robert W Reid +2 more
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The Relationship of Choline and Carnitine in the Choline Deficient Rat
The Journal of Nutrition, 1978Levels of carnitine in choline deficient and choline supplemented rats were measured in heart, skeletal muscle, plasma, and liver after various treatments. A decreased hepatic concentration of carnitine was shown to be closely correlated to the deficiency in dietary choline.
A L, Carter, R, Frenkel
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Ethanolamine on choline deficiency in rats
Archives of Biochemistry and Biophysics, 1959Abstract The addition of ethanolamine to low choline diets containing either 18 or 42% casein increased the incidence of both hemorrhagic kidneys and hemorrhagic eyes in weanling male rats consuming these diets for 7 days. At the same time the accumulation of liver fat in all animals was prevented by the added ethanolamine.
D J, MULFORD, W J, LONGMORE, G M, KREYE
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Dietary Choline Deficiency Alters Global and Gene-Specific DNA Methylation in the Developing Hippocampus of Mouse Fetal Brains. [PDF]
FASEB Journal, 2006 The availability of choline during critical periods of fetal development alters hippocampal development and affects memory function throughout life. Choline deficiency during fetal development reduces proliferation and migration of neuronal precursor ...
Steven H Zeisel +2 more
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Choline Deficiency in the Guinea Pig
Nature, 1954THE brief report by Reid1 of the “production of clear-cut deficiencies of … choline …” in the guinea pig is of considerable interest, as Handler2 had previously failed to produce fatty livers in guinea pigs maintained on a hypolipotropic diet and had correlated this failure with the low choline oxidase content of guinea pig liver8.
W G, CASSELMAN, G R, WILLIAMS
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Heart Dysfunction Induced by Choline-Deficiency in Adult Rats: The Protective Role of l-Carnitine
European Journal of Pharmacology, 2013 Choline is a B vitamin co-factor and its deficiency seems to impair heart function. Carnitine, a chemical analog of choline, has been used as adjunct in the management of cardiac diseases.
Andreas Lazaris
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