Results 31 to 40 of about 500,160 (249)
Journal of Pharmacological Sciences, 2016 We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death.
Ryohta Nishiyama +8 more
doaj +1 more source
Choline-deficiency fatty liver: impaired release of hepatic triglycerides
Journal of Lipid Research, 1968 After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly.
B. Lombardi, P. Pani, F.F. Schlunk
doaj +1 more source
Metabolites, 2022 Atherosclerosis is the most common disease of the vascular system and the metabolic disorder is one of its important molecular mechanisms. SAP protein is found to be highly expressed in atherosclerotic blood vessels.
Qian Li +8 more
doaj +1 more source
Liver Microsomal Phosphatidyl Choline Biosynthesis in Choline Deficiency
Experimental Biology and Medicine, 1974 SummaryIn choline deficiency, there is a decrease in activity of the phosphatidyl ethanolamine methyltransferase of liver microsomes. There is an impairment in the conversion of phosphatidyl ethanolamine to phosphatidyl choline via the Bremer-Green-berg pathway.
D N, Skurdal, W E, Cornatzer
openaire +2 more sources
Synthesis of phosphatidylcholine by rat lung during choline deficiency
, 1986 The effect of choline deficiency on the de novo pathway for phosphatidylcholine (PC) synthesis in the lung was investigated in rats fed a washed soy protein (lipotrophic) diet deficient in choline and methionine for 2–3 wk.
A. B. Fisher +3 more
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
, 1968 The incorporation of metabolic precursors of lipids was followed in the livers of rats fed a semisynthetic diet supplemented with, or deficient in, choline.
J. Blumenstein
core +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source