Results 41 to 50 of about 30,352 (159)

Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C

Nature Communications
BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection.
Cong Wang, Xuexia Xie, Jiahuang Li, Jiawei Zhu, Binghe Sun, Yue Wu, Wanying Zhang, Dake Li, Guo Chen   +8 more
doaj   +1 more source

The Importance of Gut Microbiota on Choline Metabolism in Neurodegenerative Diseases

Biomolecules
The gut microbiota is a complex ecosystem that influences digestion, immune response, metabolism, and has been linked to health and well-being. Choline is essential for neurotransmitters, lipid transport, cell-membrane signaling, methyl-group metabolism ...
Majid Eslami, Farnaz Alibabaei, Ali Babaeizad, Seyedeh Zahra Banihashemian, Mahdi Mazandarani, Aref Hoseini, Mohammad Ramezankhah, Valentyn Oksenych, Bahman Yousefi   +8 more
doaj   +1 more source

Choline adequacy and health outcomes in vegetarian and vegan diets

Academia Nutrition and Dietetics
Choline is an essential nutrient with roles in neurotransmitter synthesis, one-carbon metabolism, and lipid transport. Animal-derived foods such as eggs and red meat are the richest dietary sources, but increased consumption of these foods is ...
David Goldman, Matthew Nagra
doaj   +1 more source

Development and validation of a quantitative choline food frequency questionnaire for use with drinking and non-drinking pregnant women in Cape Town, South Africa

Nutrition Journal, 2018
Background Although animal and human studies have demonstrated interactions between dietary choline and fetal alcohol spectrum disorders, dietary choline deficiency in pregnancy is common in the US and worldwide.
R. Colin Carter, Sandra W. Jacobson, Sharmilah Booley, Baheya Najaar, Neil C. Dodge, Lori J. Bechard, Ernesta M. Meintjes, Christopher D. Molteno, Christopher P. Duggan, Joseph L. Jacobson, Marjanne Senekal   +10 more
doaj   +1 more source

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine-N-Oxide

mBio, 2015
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which upon absorption by the host is converted in the liver to trimethylamine-N-oxide (TMAO).
Kymberleigh A. Romano, Eugenio I. Vivas, Daniel Amador-Noguez, Federico E. Rey   +3 more
doaj   +1 more source

Choline kinase alpha genotype is related to hippocampal brain volume and cognition in postmenopausal women

Heliyon
This study examined how single nucleotide polymorphisms (SNPs) related to choline synthesis and metabolism, processes largely regulated by estrogen, influenced hippocampal volume and neuropsychological function following menopause.
Abigail J. Myers, Callum Potts, Jenna A. Makarewicz, Elizabeth McGee, Julie A. Dumas   +4 more
doaj   +1 more source

Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice. [PDF]

Sci Rep, 2023
Zhai T, Wang J, Chen Y.
europepmc   +1 more source

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice. [PDF]

Nutrients, 2021
Christensen KE, Malysheva OV, Carlin S, Matias F, MacFarlane AJ, Jacobs RL, Caudill MA, Rozen R.   +7 more
europepmc   +1 more source

Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High‐Fat Diet

FASEB BioAdvances
High‐fat diets (HFDs) are a well‐established cause of hepatic steatosis, a condition associated with altered hepatic fatty acid metabolism and reduced choline availability.
Eva Kranenburg, Ruslan Kubant, Zeyu Yang, Adam H. Metherel, Chuck T. Chen, Jacqueline L. Beaudry, Clara E. Cho, Perlina Vaz, G. Harvey Anderson   +8 more
doaj   +1 more source

Regulation by dietary choline of hepatic fatty acid synthetase in the rat

Journal of Lipid Research, 1973
Fatty acid synthetase activity was measured in the high-speed supernatant fraction of liver homogenates from rats fed a semisynthetic diet low in lipotropic factors.
Bruno Rosenfeld
doaj   +1 more source