Results 21 to 30 of about 500,160 (249)
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans [PDF]
, 2005 Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism.
Kohlmeier, M. +3 more
core +1 more source
, 2021 Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are not meeting the recommended intake requirement. Choline deficiency is
Cheam, Guoxiang +5 more
core +1 more source
Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology [PDF]
Asian-Australasian Journal of Animal Sciences, 2018 Objective The study was designed to establish choline deficiency model (CDM) in broilers for evaluating efficacy of polyherbal formulation (PHF) in comparison with synthetic choline chloride (SCC).
Ramasamy Selvam +4 more
doaj +1 more source
Serial plasma choline measurements after cardiac arrest in patients undergoing mild therapeutic hypothermia: a prospective observational pilot trial. [PDF]
PLoS ONE, 2013 OBJECTIVE: Choline is related to phospholipid metabolism and is a marker for global ischaemia with a small reference range in healthy volunteers. The aim of our study was to characterize the early kinetics of plasma free choline in patients after cardiac
Christian Storm +5 more
doaj +1 more source
Journal of Dairy Science, 2023 : Rumen-protected choline (RPC) supplementation in the periparturient period has in some instances prevented and alleviated fatty liver disease in dairy cows. Mechanistically, however, it is unclear how choline prevents the accumulation of lipid droplets
Wenyan Lu +8 more
doaj +1 more source
Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones [PDF]
, 2012 Dietary choline is an important modulator of gene expression (via epigenetic marks) and of DNA integrity. Choline was discovered to be an essential nutrient for some humans approximately one decade ago.
Steven H. Zeisel, Zeisel, Steven H.
core +1 more source
Journal of Nutritional Science, 2023 Choline was recently established as an essential nutrient for Atlantic salmon at all life stages. Choline deficiency is manifested as an excessive accumulation of dietary fat within the intestinal enterocytes, a condition known as steatosis.
Daphne Siciliani +4 more
doaj +1 more source
The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism
Biomolecules, 2023 The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent ...
Sayaka Harada +8 more
doaj +1 more source
Cells, 2022 High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai +5 more
doaj +1 more source
LIVER LIPIDS OF CHOLINE-DEFICIENT RATS [PDF]
Biochemical Journal, 1965 1. Four-week-old male and female rats were given choline-deficient diets for 2 weeks. Deficient animals gained nearly as much weight as normal controls of the same sex. 2. The amounts of triglyceride and esterified cholesterol in liver lipids were increased threefold or more by the deficiency.
J, TINOCO +4 more
openaire +2 more sources