Liver Microsomal Phosphatidyl Choline Biosynthesis in Choline Deficiency
Experimental Biology and Medicine, 1974 SummaryIn choline deficiency, there is a decrease in activity of the phosphatidyl ethanolamine methyltransferase of liver microsomes. There is an impairment in the conversion of phosphatidyl ethanolamine to phosphatidyl choline via the Bremer-Green-berg pathway.
D N, Skurdal, W E, Cornatzer
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Animal models of NASH: getting both pathology and metabolic context right [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
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Journal of Lipid Research, 1966 Rats were maintained at 2°, 21°, and 33° for 3 weeks on a choline-supplemented or a choline-deficient diet. In contrast to the findings of some other workers, choline deficiency produced fatty livers at all temperatures.The ratio of the total liver lipid
J.S. Chahl, C.C. Kratzing
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Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
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Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]
, 2010 Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin +5 more
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Diurnal changes in liver and plasma lipids of choline-deficient rats
Journal of Lipid Research, 1966 Early effects of choline deficiency were studied in rats. Nonphospholipid (“neutral lipid”) and phospholipid were measured in plasma and in three fractions of a liver homogenate:sediment, supernatant fraction, and “floating fat.”A single choline ...
Bruno Rosenfeld, Jessie M. Lang
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Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]
, 2019 Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna +6 more
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Choline Deficiency in the Hamster
Experimental Biology and Medicine, 1949 SummaryYoung hamsters develop fatty livers when fed choline deficient rations containing peanut meal, although the mean increment in liver fat is only half that found in rats on the same diet. This may be correlated with the finding that hamster livers and kidneys possess markedly less choline oxidase activity than do the livers and kidneys of rats or ...
P, HANDLER, F, BERNHEIM
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, 2019 The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production.
Barcelos, Isabella Peixoto de +1 more
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Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]
, 2016 Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano +11 more
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