Results 21 to 30 of about 30,352 (159)

Serial plasma choline measurements after cardiac arrest in patients undergoing mild therapeutic hypothermia: a prospective observational pilot trial. [PDF]

PLoS ONE, 2013
OBJECTIVE: Choline is related to phospholipid metabolism and is a marker for global ischaemia with a small reference range in healthy volunteers. The aim of our study was to characterize the early kinetics of plasma free choline in patients after cardiac
Christian Storm, Oliver Danne, Per Magne Ueland, Christoph Leithner, Dietrich Hasper, Tim Schroeder   +5 more
doaj   +1 more source

Effects of choline deficiency and supplementation on lipid droplet accumulation in bovine primary liver cells in vitro

Journal of Dairy Science, 2023
: Rumen-protected choline (RPC) supplementation in the periparturient period has in some instances prevented and alleviated fatty liver disease in dairy cows. Mechanistically, however, it is unclear how choline prevents the accumulation of lipid droplets
Wenyan Lu, Jingna Yang, Mingyue Hu, Kai Zhong, Yueying Wang, Yanbin Yang, Juan J. Loor, Guoyu Yang, Liqiang Han   +8 more
doaj   +1 more source

Effects of dietary lipid level and environmental temperature on lipid metabolism in the intestine and liver, and choline requirement in Atlantic salmon (Salmo salar L) parr

Journal of Nutritional Science, 2023
Choline was recently established as an essential nutrient for Atlantic salmon at all life stages. Choline deficiency is manifested as an excessive accumulation of dietary fat within the intestinal enterocytes, a condition known as steatosis.
Daphne Siciliani, Trond M. Kortner, Gerd M. Berge, Anne Kristine Hansen, Åshild Krogdahl   +4 more
doaj   +1 more source

The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism

Biomolecules, 2023
The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent ...
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami   +8 more
doaj   +1 more source

Dietary Choline Mitigates High-Fat Diet-Impaired Chylomicrons Assembly via UPRer Modulated by perk DNA Methylation

Cells, 2022
High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai, Hua Zheng, Zhi Luo, Christer Hogstrand, Ling-Jiao Wang, Yu-Feng Song   +5 more
doaj   +1 more source

LIVER LIPIDS OF CHOLINE-DEFICIENT RATS [PDF]

Biochemical Journal, 1965
1. Four-week-old male and female rats were given choline-deficient diets for 2 weeks. Deficient animals gained nearly as much weight as normal controls of the same sex. 2. The amounts of triglyceride and esterified cholesterol in liver lipids were increased threefold or more by the deficiency.
J, TINOCO, A, SHANNON, P, MILJANICH, R, BABCOCK, R L, LYMAN   +4 more
openaire   +2 more sources

Identification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy

Journal of Pharmacological Sciences, 2016
We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death.
Ryohta Nishiyama, Fumiaki Nagashima, Beniko Iwao, Yuiko Kawai, Kana Inoue, Arisa Midori, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inazu   +8 more
doaj   +1 more source

¹H-NMR-Based Metabonomics Study to Reveal the Progressive Metabolism Regulation of SAP Deficiency on ApoE^−/− Mice

Metabolites, 2022
Atherosclerosis is the most common disease of the vascular system and the metabolic disorder is one of its important molecular mechanisms. SAP protein is found to be highly expressed in atherosclerotic blood vessels.
Qian Li, Wanting Chen, Wenbin Huang, Ranran Hou, Xinping Huang, Man Xu, Limei Que, Lijing Wang, Yongxia Yang   +8 more
doaj   +1 more source

Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice

Journal of Obesity, 2012
Previous studies demonstrated that choline supply is directly linked to high-fat-diet-induced obesity and insulin resistance in mice. The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a ...
Gengshu Wu, Liyan Zhang, Tete Li, Gary Lopaschuk, Dennis E. Vance, René L. Jacobs   +5 more
doaj   +1 more source

Choline-deficiency fatty liver: impaired release of hepatic triglycerides

Journal of Lipid Research, 1968
After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly.
B. Lombardi, P. Pani, F.F. Schlunk
doaj   +1 more source