Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
Nature Communications, 2023 Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic choline. However,
Ryutaro Tamura +19 more
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Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency. [PDF]
PLoS ONE, 2017 Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated.
Shintaro Sagami +9 more
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Revista Brasileira de Zootecnia, 2023 The objective of this study was to evaluate the effects of replacing choline chloride with a plant source of choline on the locomotor system, liver health, and development of breast myopathies in broilers aged 1-42 days of age. We allocated 1,120 one-day-
Allan Gabriel Ferreira Dias +7 more
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A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors. [PDF]
PLoS ONE, 2017 The liver and intestine are susceptible to the oxidative damage which could result in several diseases. Choline deficiency induced oxidative damage in rat liver cells.
Pei Wu +7 more
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Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. [PDF]
PLoS ONE, 2015 Few studies have evaluated the impact of dietary choline on the health and well-being of swine, and those pivotal papers were aimed at determining dietary requirements for sows and growing pigs.
Caitlyn M Getty, Ryan N Dilger
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Cells, 2021 Choline and choline metabolites are essential for all cellular functions. They have also been reported to be crucial for neural development. In this work, we studied the functional characteristics of the choline uptake system in human neural stem cells ...
Yosuke Fujita +4 more
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Severe choline deficiency induces alternative splicing aberrance in optimized duck primary hepatocyte cultures [PDF]
Animal Bioscience, 2022 Objective Choline deficiency, one main trigger for nonalcoholic fatty liver disease (NAFLD), is closely related to lipid metabolism disorder. Previous study in a choline-deficient model has largely focused on gene expression rather than gene structure ...
Lulu Zhao +5 more
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Lipoproteins in Choline Deficiency [PDF]
Circulation Research, 1955 Choline deficiency leads to lipomatous infiltration of the coronary arteries and to aortic sclerosis of the Moenckeberg type in young rats. In this form of experimental cardiovascular disease the total serum cholesterol and the triglyceride-bearing lipoproteins are decreased. The beta-lipoprotein classes are essentially within normal limits.
G F, WILGRAM, L A, LEWIS, J, BLUMENSTEIN
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ON THE BIOLOGICAL ROLE OF CHOLINE IN HUMAN AND HIGHER ANIMAL ORGANISMS (A LITERATURE REVIEW)
Siberian Journal of Life Sciences and Agriculture, 2021 Purpose. To provide the reader a detailed literature review regarding the history of the discovery of choline, then the history of further research on its biological role in human and higher animal organisms.
Roman A. Bekker +2 more
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Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. [PDF]
PLoS ONE, 2013 Though widely employed for clinical intervention in obesity, metabolic syndrome, seizure disorders and other neurodegenerative diseases, the mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be ...
Rebecca C Schugar +4 more
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