Results 1 to 10 of about 30,352 (159)

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis [PDF]

Nature Communications, 2023
Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic choline. However,
Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, Tatsuya Okamoto, Seiichi Shimizu, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Satoru Takahashi, Hiroyuki Kusuhara, Yoh Zen, Tomohiro Ando, Hisamitsu Hayashi   +19 more
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Severe choline deficiency induces alternative splicing aberrance in optimized duck primary hepatocyte cultures [PDF]

Animal Bioscience, 2022
Objective Choline deficiency, one main trigger for nonalcoholic fatty liver disease (NAFLD), is closely related to lipid metabolism disorder. Previous study in a choline-deficient model has largely focused on gene expression rather than gene structure ...
Lulu Zhao, Hongying Cai, Yongbao Wu, Changfu Tian, Zhiguo Wen, Peilong Yang   +5 more
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Choline Deficiency Drives the Inflammation–Fibrosis Cascade: A Spatiotemporal Atlas of Hepatic Injury from Weeks 6 to 10 [PDF]

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly linked to systemic metabolic disturbances and features a lipid-driven cascade that promotes hepatic inflammation and fibrosis.
Shang Li, Guoqiang Zhang, Xiaohong Li, Xu Zhao, Axi Shi, Qingmin Dong, Changpeng Chai, Xiaojing Song, Yuhui Wei, Xun Li   +9 more
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Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. [PDF]

PLoS ONE, 2015
Few studies have evaluated the impact of dietary choline on the health and well-being of swine, and those pivotal papers were aimed at determining dietary requirements for sows and growing pigs.
Caitlyn M Getty, Ryan N Dilger
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Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The study was designed to establish choline deficiency model (CDM) in broilers for evaluating efficacy of polyherbal formulation (PHF) in comparison with synthetic choline chloride (SCC).
Ramasamy Selvam, Marimuthu Saravanakumar, Subramaniyam Suresh, CV Chandrasekeran, D’Souza Prashanth   +4 more
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Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt [PDF]

Scientific Reports
The well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic role remains unknown.
Martha Ghebreselassie, Yoo Jin Park, Diana Nakib, David Dodington, Parasvi Patel, Sohyun Won, Anne Hakem, Razqallah Hakem, Sonya MacParland, Minna Woo   +9 more
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Choline in Adolescent Pregnancy: The Impact on Fetal Brain Development and Long-Term Cognitive Outcomes of Offspring [PDF]

Medicina
Pregnancy in adolescence represents a major nutritional challenge, with competing demands between maternal development and fetal growth. Choline is the essential nutrient with a critical role for fetal brain development and exhibits distinct metabolic ...
Abdul Jabar Khudor, Marius Alexandru Moga, Oana Gabriela Dimienescu, Andrada Camelia Nicolau, Cristian Andrei Arvătescu, Mircea Daniel Hogea, Natalia Ciobanu   +6 more
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TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream [PDF]

Communications Biology
Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi).
Eva Drevet Mulard, Iliass Imam, Pierre-Damien Coureux, Anne Briolay, Laurence Bessueille, Antoine Tarby, Stéphane Balayssac, Sonoko Narisawa, Felix Lecornu, Véronique Gilard, Sébastien Violot, Jose Luis Millan, Gilles Jean Philippe Rautureau, Lionel Ballut, David Magne   +14 more
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Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats [PDF]

The Scientific World Journal, 2014
Betaine is an important natural component of rich food sources, especially spinach. Rats were fed diets with betaine or spinach powder at the same level of betaine for 10 days to investigate the dose-dependent effects of spinach powder supplementation on
Yi-Qun Liu, Zheng Jia, Feng Han, Takahiro Inakuma, Tatsuya Miyashita, Kimio Sugiyama, Li-Cui Sun, Xue-Song Xiang, Zhen-Wu Huang   +8 more
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Functional Expression of Choline Transporters in Human Neural Stem Cells and Its Link to Cell Proliferation, Cell Viability, and Neurite Outgrowth

Cells, 2021
Choline and choline metabolites are essential for all cellular functions. They have also been reported to be crucial for neural development. In this work, we studied the functional characteristics of the choline uptake system in human neural stem cells ...
Yosuke Fujita, Tomoki Nagakura, Hiroyuki Uchino, Masato Inazu, Tsuyoshi Yamanaka   +4 more
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