Results 1 to 10 of about 59,216 (179)

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis. [PDF]

Nat Commun, 2023
Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic choline. However,
Tamura R, Sabu Y, Mizuno T, Mizuno S, Nakano S, Suzuki M, Abukawa D, Kaji S, Azuma Y, Inui A, Okamoto T, Shimizu S, Fukuda A, Sakamoto S, Kasahara M, Takahashi S, Kusuhara H, Zen Y, Ando T, Hayashi H.   +19 more
europepmc   +2 more sources

Severe choline deficiency induces alternative splicing aberrance in optimized duck primary hepatocyte cultures. [PDF]

Anim Biosci, 2022
Objective Choline deficiency, one main trigger for nonalcoholic fatty liver disease (NAFLD), is closely related to lipid metabolism disorder. Previous study in a choline-deficient model has largely focused on gene expression rather than gene structure ...
Zhao L, Cai H, Wu Y, Tian C, Wen Z, Yang P.   +5 more
europepmc   +2 more sources

Role of choline deficiency in the fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet [PDF]

PLoS ONE, 2013
Though widely employed for clinical intervention in obesity, metabolic syndrome, seizure disorders and other neurodegenerative diseases, the mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be ...
Brunt, Elizabeth M, Crawford, Peter A, Huang, Xiaojing, Moll, Ashley R, Schugar, Rebecca C   +4 more
core   +5 more sources

Choline Deficiency Drives the Inflammation-Fibrosis Cascade: A Spatiotemporal Atlas of Hepatic Injury from Weeks 6 to 10. [PDF]

Antioxidants (Basel)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly linked to systemic metabolic disturbances and features a lipid-driven cascade that promotes hepatic inflammation and fibrosis.
Li S, Zhang G, Li X, Zhao X, Shi A, Dong Q, Chai C, Song X, Wei Y, Li X.   +9 more
europepmc   +2 more sources

Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology. [PDF]

Asian-Australas J Anim Sci, 2018
Objective The study was designed to establish choline deficiency model (CDM) in broilers for evaluating efficacy of polyherbal formulation (PHF) in comparison with synthetic choline chloride (SCC).
Selvam R, Saravanakumar M, Suresh S, Chandrasekeran CV, Prashanth D.   +4 more
europepmc   +2 more sources

Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. [PDF]

PLoS One, 2015
Few studies have evaluated the impact of dietary choline on the health and well-being of swine, and those pivotal papers were aimed at determining dietary requirements for sows and growing pigs.
Getty CM, Dilger RN.
europepmc   +2 more sources

Choline in Adolescent Pregnancy: The Impact on Fetal Brain Development and Long-Term Cognitive Outcomes of Offspring. [PDF]

Medicina (Kaunas)
Pregnancy in adolescence represents a major nutritional challenge, with competing demands between maternal development and fetal growth. Choline is the essential nutrient with a critical role for fetal brain development and exhibits distinct metabolic ...
Khudor AJ, Moga MA, Dimienescu OG, Nicolau AC, Arvătescu CA, Hogea MD, Ciobanu N.   +6 more
europepmc   +2 more sources

TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream. [PDF]

Commun Biol
Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi).
Drevet Mulard E, Imam I, Coureux PD, Briolay A, Bessueille L, Tarby A, Balayssac S, Narisawa S, Lecornu F, Gilard V, Violot S, Millan JL, Rautureau GJP, Ballut L, Magne D.   +14 more
europepmc   +2 more sources

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to choline and “development of brain” pursuant to Article 14 of Regulation (EC) No 1924/2006 [PDF]

EFSA Journal, 2014
Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products ...

core   +3 more sources

Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. [PDF]

ScientificWorldJournal, 2014
Betaine is an important natural component of rich food sources, especially spinach. Rats were fed diets with betaine or spinach powder at the same level of betaine for 10 days to investigate the dose-dependent effects of spinach powder supplementation on
Liu YQ, Jia Z, Han F, Inakuma T, Miyashita T, Sugiyama K, Sun LC, Xiang XS, Huang ZW.   +8 more
europepmc   +2 more sources