Results 81 to 90 of about 500,160 (249)

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Induction of Renal Hypertension in Rats and Dogs by Potassium or Choline Deficiency

, 1958
The maintenance of rats and dogs on a choline- or potassium-free diet for periods of 1–4 weeks after weaning results in the development of hypertensive cardiovascular disease.
Arthur Grollman, Fred N. White
core   +1 more source

Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration

, 2020
Cerebral choline metabolism is crucial for normal brain function, and its homoeostasis depends on carrier-mediated transport. Here, we report on four individuals from three families with neurodegenerative disease and homozygous frameshift mutations ...
Tarnopolsky, Mark, Agarwal, Prasoon, Jamra, Rami A, Wieczorek, Dagmar, Hejbøl, Eva Kildall, Nagy, Peter, Taylor, Adrian, Dolinsky, Vernon W, Klee, Dirk, Fagerberg, Christina R; id_orcid, Schrøder, Henrik D; id_orcid, Gade, Else, Bakovic, Marica, Brady, Lauren, Markovic, Ljubo, Rouse, Nicholas, Distelmaier, Felix, Kibæk, Maria, Larsen, Martin J; id_orcid, Seibt, Annette   +19 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Choline-containing metabolite amplitude changes in synthetic data.

, 2017
Amplitudes of choline (CHO, red) and the combined phosphocholine/glycerophosphocholine peak (PHC/GPC, blue) estimated using the MOD_CHOsep (top) and MOD_CHOglobal (bottom) models in synthetic data. Estimated levels of CHO (red) and PHC/GPC (blue) show an
Paul Gerald Mullins (3743626), Somya Iqbal (3743635), Tiffany Bell (3743632), Anastasia Christakou (3743629), Michael Lindner (383308)   +4 more
core   +1 more source

Accumulation of 1, 2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. [PDF]

, 1993
Choline deficiency, via deprivation of labile methyl groups, is associated with a greatly increased incidence of hepatocarcinoma in experimental animals.

core   +1 more source

Choline adequacy and health outcomes in vegetarian and vegan diets

Academia Nutrition and Dietetics
Choline is an essential nutrient with roles in neurotransmitter synthesis, one-carbon metabolism, and lipid transport. Animal-derived foods such as eggs and red meat are the richest dietary sources, but increased consumption of these foods is ...
David Goldman, Matthew Nagra
doaj   +1 more source

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load [PDF]

, 2005
Elevated concentrations of homocysteine in blood may be an independent risk factor for the development of atherosclerosis. Elevated homocysteine concentrations can be caused by decreased methylation of homocysteine to form methionine, as occurs in folate
Gaffney, Christopher E., Da Costa, Kerry Ann, Fischer, Leslie M., Zeisel, Steven H.   +3 more
core   +1 more source

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine-N-Oxide

mBio, 2015
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which upon absorption by the host is converted in the liver to trimethylamine-N-oxide (TMAO).
Kymberleigh A. Romano, Eugenio I. Vivas, Daniel Amador-Noguez, Federico E. Rey   +3 more
doaj   +1 more source

Innervation of the tubarial glands: A hypothesis‐driven anatomical review

The Anatomical Record, EarlyView.
Abstract The tubarial glands have been described as a macroscopic bilateral glandular complex in the posterolateral nasopharynx near the torus tubarius and the pharyngeal opening of the Eustachian tube. Since their recognition on prostate‐specific membrane antigen‐based imaging, their anatomical classification has remained debated, with converging ...
Mugurel Constantin Rusu, Ivan Varga, Răzvan Costin Tudose   +2 more
wiley   +1 more source