Results 131 to 140 of about 51,688 (341)

Neuroprotective Potential of New Monoterpene-Adamatane Conjugates—A Pilot Study

open access: yesCurrent Issues in Molecular Biology
Neurodegenerative diseases, including Alzheimer’s disease, are marked by cholinergic dysfunction, oxidative stress, and reduced neurotrophic support, which drives the quest for multifunctional therapeutic agents.
Stela Dragomanova   +18 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

open access: yesObesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey   +7 more
wiley   +1 more source

Adverse outcomes between VMAT2 and anticholinergics in tardive dyskinesia: A target trial emulation

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Aim Vesicular monoamine transporter 2 (VMAT2) inhibitors have been approved for the treatment of tardive dyskinesia (TD), whereas anticholinergic agents are still widely used for this condition. This study aimed to compare the risk of major clinical adverse outcomes among patients with TD treated with VMAT2 inhibitors versus anticholinergic agents ...
Tien‐Wei Hsu   +13 more
wiley   +1 more source

Characterizing social motivation deficits in treatment‐resistant schizophrenia: Evidence from social incentive performance

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Aim The Treatment‐Response‐and‐Resistance‐in‐Psychosis (TRRIP) criteria recognizes negative symptoms as defining features for treatment‐resistant schizophrenia (TRS). Social motivation refers to the desire to pursue social reward (and to avoid social punishment).
Simon S.Y. Lui   +11 more
wiley   +1 more source

Pathophysiology of Alzheimer’s Disease

open access: yesJournal of Ardabil University of Medical Sciences, 2017
Alzheimer's disease (AD) is a common cause of dementia in elderly people that is accompanied by progressive cognitive decline and memory loss. The pathologic hallmarks of AD are synaptic and neuronal degeneration together with extracellular senile ...
Mohammad Amani
doaj  

Cholinergic Supersensitivity Associated with Inferior Division Oculomotor Nerve Palsies

open access: yes, 2013
We describe three patients with inferior division cranial nerve three palsy and associated supersensitivity of their mydriatic pupils to cholinergic agents.
Alan J. Franklin, MD, PhD; S. Cruz-Flores, MD; S. Chung, MD; J. Selhorst, MD
core  

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