Results 141 to 150 of about 51,688 (341)

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Action of cholecystokinin and cholinergic agents on calcium transport in isolated pancreatic acinar cells. [PDF]

, 1975
Jerry D. Gardner, Thomas P. Conlon, H L Kleveman, Trent D. Adams, Miguel A. Ondetti   +4 more
openalex   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

The Blue Delirium: Serotonin and Anticholinergic Toxicity in a 95‐Year‐Old Woman

Journal of the American Geriatrics Society, EarlyView.
Camila S. Badell, Kathleen Brodowski, Eloy F. Ruiz, Eric Tien Yen Chyn   +3 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

Natural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato, Lucia Caputo, Laura De Martino, Daniela Grulova, Barbara Borczak, Joanna Kapusta‐Duch, Vincenzo De Feo   +6 more
wiley   +1 more source

Identifying Donepezil-Like Compounds Against Acetylcholinesterase Using Molecular Docking, Dynamic Simulation, ADMET, and PCA: Therapeutic Management of Alzheimer’s Disease

Journal of Chemistry
Alzheimer’s disease (AD) is a significant concern in the elderly, characterized by impaired cholinergic transmission,decreased choline acetyltransferase activity and increased acetylcholinesterase (AChE) activity, resulting in reduced acetylcholine ...
Yinsheng Yang, Akhtar Atiya, Mohammed Alrouji, Mohammed S. Alshammari, Sharaf E. Sharaf, Dharmendra Kumar Yadav, Saad Ali Alshehri, Moyad Shahwan, Anas Shamsi   +8 more
doaj   +1 more source

The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics. [PDF]

Psychophysiology
ABSTRACT Spontaneous pupil fluctuations (SPFs) during rest provide a non‐invasive, low‐cost index of central arousal dynamics, independent of cognitive task demands. These features position SPFs as promising markers for baseline neurophysiological activity in both basic and translational research. This review synthesizes current evidence on the resting‐
Liu T, Kotz SA, Criscuolo A, Schwartze M.   +3 more
europepmc   +2 more sources

Co-pathologies and biological processes beyond amyloid-beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies. [PDF]

J Intern Med
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Ferreira D, Chmiela T, Eriksdotter M, Jack CR, Kalpouzos G, Marseglia A, Mecocci P, Nordberg A, Religa D, Westman E.   +9 more
europepmc   +2 more sources

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source