Results 111 to 120 of about 746,801 (362)

Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

RUDN Journal of Medicine, 2011
This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both ...
V I Torshin, V M Smirnov, D S Sveshnikov, A V Kuchuk, I A Yurasova   +4 more
doaj  

Applicability of Anticholinergic Risk Scale in hospitalized elderly persons

Revista Brasileira de Geriatria e Gerontologia, 2017
Objective: to define the applicability of the Anticholinergic Risk Scale (ARS) as a risk indicator of delirium in hospitalized elderly persons. Method: the medical records of elderly patients hospitalized in the medical wards of a teaching hospital were
Milton Luiz Gorzoni, Renato Moraes Alves Fabbri   +1 more
doaj   +2 more sources

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core  

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

Molecular Metabolism, 2015
Objective: Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis.
Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo   +7 more
doaj   +1 more source

GABA_{B} Receptors Regulate Chick Retinal Calcium Waves [PDF]

, 2001
Correlated spiking activity and associated Ca²⁺ waves in the developing retina are important in determining the connectivity of the visual system. Here, we show that GABA, via GABA_{B} receptors, regulates the temporal characteristics of Ca²⁺ waves ...
Catsicas, M, Mobbs, P
core  

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, EarlyView.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

Control failure risk, resistance and enzymatic activity of neurotoxic insecticides in Brazilian populations of Leucoptera coffeella (Lepidoptera: Lyonetiidae)

Pest Management Science, EarlyView.
Bioassays of 36 Leucoptera coffeella populations revealed resistance to neurotoxic insecticides, control failures of ≤62.9% and enzyme activity variation, with particularly high GST and low AChE levels. Abstract Background Leucoptera coffeella is a key pest of coffee crops in Brazil, causing significant damage by mining coffee leaves.
Daianna P. Costa, Carlos G. da Cruz, Ryan F. S. e Silva, Liliane E. Visôtto, Jesús E. Gomez, Marisol Giraldo‐Jaramillo, Flávio L. Fernandes   +6 more
wiley   +1 more source

Combined β-Adrenergic and Cholinergic Antagonism Produces Behavioral and Cognitive Impairments in the Water Maze: Implications for Alzheimer Disease and Pharmacotherapy with β-Adrenergic Antagonists [PDF]

, 2003
Andrea J Saber, Donald P. Cain
openalex   +1 more source