Results 1 to 10 of about 87,987 (161)

Acetylcholine and cholinergic receptors [PDF]

open access: yesBrain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic ...
David A. Brown
doaj   +6 more sources

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission [PDF]

open access: yesCell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan   +11 more
doaj   +2 more sources

Hippocampus and Entorhinal Cortex Recruit Cholinergic and NMDA Receptors Separately to Generate Hippocampal Theta Oscillations

open access: yesCell Reports, 2017
Summary: Although much progress has been made in understanding type II theta rhythm generation under urethane anesthesia, less is known about the mechanisms underlying type I theta generation during active exploration.
Zhenglin Gu   +3 more
doaj   +3 more sources

Adrenergic and cholinergic receptors of cerebral microvessels. [PDF]

open access: yesJournal of Cerebral Blood Flow and Metabolism, 1981
The presence of α- and β-adrenergic and muscarinic cholinergic receptors in cerebral microvessels of the rat and pig was assessed by ligand binding techniques. The results demonstrate the presence of specific binding to α 2 - and β-adrenergic receptors but no appreciable specific binding to α
Shailesh P Banerjee   +2 more
exaly   +3 more sources

Cholinergic receptors in aging and Alzheimer's disease

open access: yesProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1986
Although Alzheimer's disease (AD) is a disorder involving multiple neurotransmitter systems, the basal forebrain cholinergic system (Ch system) is severely and consistently affected in this condition. In both animals and man, the nature of age-associated alterations in the Ch system is unclear. In addition, available studies of cholinergic receptors in
Peter Whitehouse
exaly   +3 more sources

Beta-adrenergic and M-cholinergic receptor interactions in the pathogenesis of bronchial obstructive pulmonary diseases [PDF]

open access: yesКлиническая практика, 2020
The crosstalk between the beta-2-adrenoceptor and M- cholinoreceptor systems in the airways plays one of the main roles in the pathogenesis of bronchoobstructive diseases.
Anna V. Eremenko, Kirill A. Zykov
doaj   +1 more source

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

open access: yesNature Communications, 2023
The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost   +11 more
doaj   +1 more source

Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri

open access: yesBrain Sciences, 2020
Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons.
Paolo de Girolamo   +5 more
doaj   +1 more source

Cholinergic Receptors in Cognitive Disorders [PDF]

open access: yesCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1986
Abstract:Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have been examined in the hippocampus obtained at autopsy from a variety of patients with cognitive disorders (Alzheimer's, Parkinson's, and Huntington's diseases, Down's Syndrome and alcoholic dementia) and compared with neurologically normal controls and ...
Perry EK   +8 more
openaire   +2 more sources

Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy

open access: yesFrontiers in Pharmacology, 2018
Nicotinic acetylcholine receptors (nAChRs) expressed on the cell plasma membrane are ligand-gated ion channels mediating fast synaptic transmission, regulating neurotransmitter and cytokine release and supporting the viability of many cell types.
Kateryna Uspenska   +6 more
doaj   +1 more source

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