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Cholinergic innervation and receptors in the cerebellum.
Progress in brain research, 1997We have studied the source and ultrastructural characteristics of ChAT-immunoreactive fibers in the cerebellum of the rat, and the distribution of muscarinic and nicotinic receptors in the cerebellum of the rat, rabbit, cat and monkey, in order to define which of the cerebellar afferents may use ACh as a neurotransmitter, what target structures are ...
Jaarsma, Dick +6 more
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Cholinergic receptors in corpora cavernosa
Urology, 1984In a group of 13 patients who underwent penile surgery, a small amount of cavernosal tissue was removed and examined for content of cholinergic receptors. Three patients did not display any amount of cholinergic receptors. Values in the other 10 patients ranged from 34 to 136 femtomols.
C J, Godec, H, Bates
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Immunohistochemistry of cholinergic receptors
Anatomy and Embryology, 1992Acetylcholine and its receptors are involved in a variety of important signal transduction processes. As shown here paradigmatically for the human neuromuscular junction and the cerebral cortex, acetylcholine receptors can be visualized immunohistochemically at the cellular and subcellular level under physiological and pathological conditions.
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Presynaptic muscarinic cholinergic receptors
Nature, 1978IN the isolated rabbit heart, acetylcholine inhibits the release of noradrenaline evoked by nicotinic drugs1, by KCl (ref. 2) and by sympathetic nerve stimulation3. The release of noradrenaline in response to sympathetic nerve stimulation in the rabbit heart was found to be reduced by para-sympathomimetic agonists, and atropine antagonised this effect ...
V K, Sharma, S P, Banerjee
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Cholinergic receptors and neurodegenerative diseases
Pharmaceutica Acta Helvetiae, 2000Publisher Summary This chapter focuses on cholinergic receptors and neurodegenerative diseases. Known as the “cholinergic hypothesis of Alzheimer's disease (AD),” this hypothesis has served as the main rationale for the development of anti-AD drugs, even if alternative approaches, such as the use of neurotrophic agents, nootropics, glutamate ...
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Affinity Chromatography of Cholinergic Receptor Proteins
Journal of Receptor Research, 1984Cholinergic binding proteins were purified from torpedo electric organ. The preparation comprises: solubilization by non-ionic detergents followed by unspecific prepurification. For prepurification the double reversed technique proved to be very useful. Finally we applied affinity chromatography.
W H, Hopff, D M, Bodmer, P G, Waser
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Cholinergic Receptors in the Human vas Deferens
Journal of Receptor Research, 1992This study represents the first investigation demonstrating the contractile response to exogenous acetylcholine (ACh) in the isolated human vas deferens. Pharmacological characterization of cholinergic receptors was achieved using selective antagonists to define receptor subtypes.
H F, Miranda +8 more
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Cholinergic receptors in the Aplysia gill
Journal of Neurobiology, 1984AbstractAcetylcholine has been suggested as a neurotransmitter released in the Aplysia gill by peripheral afferents of central neurons and by peripheral neurons within the gill. The perfused gill, isolated from the abdominal ganglion, was examined. At concentrations greater than 1 μM, acetylcholine elicited a slowly developing tonic contraction of the ...
S, Weiss +3 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues
Journal of Ocular Pharmacology and Therapeutics, 1985Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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Receptors in neurodegenerative diseases, muscarinic cholinergic receptors
Pharmaceutica Acta Helvetiae, 2000Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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