Results 1 to 10 of about 107,703 (261)

Neuronal Nicotinic Receptors as New Targets for Amphetamine-Induced Oxidative Damage and Neurotoxicity [PDF]

Pharmaceuticals, 2011
Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) are widely abused drugs in a recreational context.
Elena Escubedo, Sara Garcia-Ratés, Jordi Camarasa, David Pubill   +3 more
doaj   +2 more sources

Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases

Membranes, 2021
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention.
Virginia Borroni, Francisco J. Barrantes
doaj   +1 more source

Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear

Frontiers in Neuroscience, 2021
Stimulation of cholinergic efferent neurons innervating the inner ear has profound, well-characterized effects on vestibular and auditory physiology, after activating distinct ACh receptors (AChRs) on afferents and hair cells in peripheral endorgans ...
Choongheon Lee, Anjali K. Sinha, Kenneth Henry, Kenneth Henry, Anqi W. Walbaum, Peter A. Crooks, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +8 more
doaj   +1 more source

Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum

Frontiers in Endocrinology, 2023
In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak, Stephanie Constantin, Jill Flannery, Susan Wray   +3 more
doaj   +1 more source

Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability

Frontiers in Cellular Neuroscience, 2022
The functional role of the mammalian efferent vestibular system (EVS) is not fully understood. One proposal is that the mammalian EVS plays a role in the long-term calibration of central vestibular pathways, for example during development.
Hui Ho Vanessa Chang, Barbara J. Morley, Kathleen E. Cullen, Kathleen E. Cullen, Kathleen E. Cullen, Kathleen E. Cullen   +5 more
doaj   +1 more source

Cholinergic Signaling, Neural Excitability, and Epilepsy

Molecules, 2021
Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission ...
Yu Wang, Bei Tan, Yi Wang, Zhong Chen
doaj   +1 more source

Bulbar dysfunction: An early presentation of congenital myasthenic syndrome in three infants

Journal of Pediatric Neurosciences, 2011
Congenital myasthenic syndromes are a group of rare genetic disorders affecting neuromuscular transmission. A high index of suspicion is required as clinical manifestations can be variable and nonspecific.
Arif Khan, Nahin Hussain, Jayaprakash A Gosalakkal   +2 more
doaj   +1 more source

Evolution in Neuromodulation—The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices

Frontiers in Neural Circuits, 2018
This review contrasts the neuromodulatory influences of acetylcholine (ACh) on the relatively conserved primary visual cortex (V1), compared to the newly evolved dorsolateral prefrontal association cortex (dlPFC).
Veronica C. Galvin, Amy F. T. Arnsten, Min Wang   +2 more
doaj   +1 more source

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

Frontiers in Cellular Neuroscience, 2017
Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere their roles are less well-understood.
Sean B. Christensen, Arik J. Hone, Isabelle Roux, Julie Kniazeff, Jean-Philippe Pin, Grégory Upert, Denis Servent, Elisabeth Glowatzki, Elisabeth Glowatzki, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +11 more
doaj   +1 more source

Exposure to Kynurenic Acid during Adolescence Increases Sign-tracking and Impairs Long-term Potentiation in Adulthood

Frontiers in Behavioral Neuroscience, 2015
Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of schizophrenia, as well as the propensity to develop co-occurring substance abuse disorders.
Nicole eDeAngeli, Travis eTodd, Stephen eChang, Hermes eYeh, Pamela eYeh, David John Bucci   +5 more
doaj   +1 more source