Results 11 to 20 of about 107,703 (261)

Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Lee R, Kim G, Black ER, Kim S.
europepmc   +2 more sources

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure [PDF]

, 2012
Background: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking ...
Timpson, NJ, Upton, Mark N, Johnstone, Elaine, Vineis, Paolo, Morris, Richard W, Johnson, Paul C. D., Johnson, P.C.D., Uhl, GR, Amuzu, A., Aveyard, P., Munafò, Marcus R., Sattar, N, Watt, G., Walther, Donna, Ebrahim, S, Timofeeva, M.N., Hingorani, AD, Upton, M.N., Morris, Richard W., Johnson, PC, Riboli, E., Munafò, Marcus R, Watt, Graham, Ebrahim, Shah, Relton, C., Jefferis, BJ, Timofeeva, Maria N., Casas, Juan P., Riboli, E, Riboli, Elio, Padmanabhan, S., Palmer, T.M., Prieto-Merino, D, Jefferis, Barbara J., Vineis, P., Munafo, M.R., Amuzu, Antoinette, Prieto-Merino, D., ?, ?, Brennan, P., Hingorani, Aroon D, Padmanabhan, Sandosh, Uhl, G.R., Morris, RW, Uhl, George R, Prieto-Merino, David, Johnson, Paul CD, Timpson, Nicholas J., Whincup, PH, Whincup, P.H., Palmer, Tom M, Johnstone, E.C., Sattar, N., Johnstone, Elaine C., Johnson, Paul C D, Hingorani, A.D., Jefferis, B.J., Brennan, P, Upton, Mark N., Davey Smith, George, Upton, MN, EPIC Study Group, Ebrahim, S., Davey Smith, G, Jefferis, Barbara J, Whincup, Peter H, Uhl, George R., Timofeeva, MN, Timofeeva, Maria N, Aveyard, P, Timpson, Nicholas J, Relton, Caroline, Sattar, Naveed, Casas, Juan P, Amuzu, A, Brennan, Paul, Munafò, MR, Palmer, TM, Relton, C, Walther, D., Vineis, P, Timpson, N.J., Watt, G, Hingorani, Aroon D., Casas, JP, Johnstone, Elaine C, Padmanabhan, S, Casas, J.P., Davey Smith, G., Palmer, Tom M., Johnstone, EC, Walther, D, Whincup, Peter H., Morris, R.W., Aveyard, Paul   +94 more
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Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex [PDF]

, 2011
The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infusion into the ...
Warburton, E Clea, Endean, E. P. E., Fontaine-Palmer, N. S., Chris J. Tinsley, Endean, Emma P E, Aggleton, John P, John P. Aggleton, Emma P.E. Endean, Vincent, Maria, Aggleton, John Patrick, Maria Vincent, E. Clea Warburton, Nadine S. Fontaine-Palmer, Brown, M. W., Malcolm W. Brown, Tinsley, Chris J, Brown, Malcolm W, Vincent, M., Tinsley, C. J., Fontaine-Palmer, Nadine S, Warburton, E. C.   +20 more
core   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
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NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD⁺ biosynthesis. [PDF]

Mol Oncol
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Oh MJ, Jang JY, Jeon Y, Kim GC, Lee H, Lee J, Kim JH, Kim H, Kim M, Kwon HK, Lee H, Kim HS.   +11 more
europepmc   +2 more sources

Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids [PDF]

, 2012
This dissertation primarily describes structure-function studies of the nicotinic acetylcholine receptors (nAChRs). These studies use a combination of unnatural amino acid mutagenesis and electrophysiology to determine the specific molecular interactions
Puskar, Nyssa Leigh
core   +1 more source

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

eLife, 2022
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cellular
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester   +18 more
doaj   +1 more source

Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista

Frontiers in Cellular Neuroscience, 2017
In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs) synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells.
Xiaorong Xu Parks, Donatella Contini, Paivi M. Jordan, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +5 more
doaj   +1 more source

Nicotinic-Acid-Ornamented Tetrameric Rare-Earth-Substituted Phospho(III)tungstates with the Coexistence of Mixed Keggin/Dawson Building Blocks and Its Honeycomb Nanofilm for Detecting Toxins

, 2021
A fascinating class of nicotinic-acid-ornamented tetrameric rare-earth (RE)-substituted phospho­(III)­tungstates [NH2(CH3)2]10Na4H8[RE2(NA)­(HNA)­(H2O)6(W2O4)­(β-H2P2IIIW13O49)­(α-HPIIIW9O33)]2·22 H2O [RE = Nd3+ (1-Nd), Tb3+ (2-Tb), Dy3+ (3-Dy), Ho3+ (4 ...
Lijuan Chen, Junwei Zhao (1444117), Lulu Liu (793645), Lulu Liu, Lijuan Chen (150349), Yanzhou Li (1726096), Guoping Liu, Guoping Liu (4584502), Tiantian Gong, Yanzhou Li, Junwei Zhao, Tiantian Gong (11086178)   +11 more
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