Results 31 to 40 of about 107,703 (261)

Cholinergic modulation in the vertebrate auditory pathway

Frontiers in Cellular Neuroscience
Acetylcholine (ACh) is a prevalent neurotransmitter throughout the nervous system. In the brain, ACh is widely regarded as a potent neuromodulator. In neurons, ACh signals are conferred through a variety of receptors that influence a broad range of ...
Chao Zhang, R. Michael Burger
doaj   +1 more source

Determination of niacin profiles in some animal and plant based foods by high performance liquid chromatography: association with healthy nutrition

Journal of Animal Science and Technology, 2019
Vitamin B3 (niacin) is essential for all living cells and plays a central role in energy metabolism and oxidative phosphorylation. Vitamin B3, a water-soluble vitamin, is present in the form of nicotinic
Jale Çatak
doaj   +1 more source

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity [PDF]

, 2010
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes.
Kaprio J, Pillai S, Martin NG, Saccone NL, Leppert Mark F., Marissa A Ehringer, Wang, Jen C., Witt, Stephanie H., Jensen, Majken K., Sarah H. Stephens, Younghun Han, Peter Kraft, Amos Christopher I., Robert B Weiss, Culverhouse, Robert C., Broderick Peter, Stephanie H Witt, Bierut Laura J., Maria Teresa L, Culverhouse Robert C., Breslau Naomi, Markus M. Nöthen, Gapstur Susan M., Niu, Tianhua, Jen C Wang, Han, Younghun, Witt Stephanie H., Heliovaara, Markku, Thomas J Payne, Andrew C. Heath, Han, Shizhong, Landi MT, Kaprio, Jaakko, Yang BZ, Martin, Nicholas G., Gapstur, Susan M., Kendler KS, Wheeler William, Yufei Wang, Witt SH, Kendler Kenneth S., Wheeler, William, John P. Rice, Kaisu Keskitalo-Vuokko, Hunter David J., Margaret R Spitz, Sarah H Stephens, Ann Schwartz, Spitz, Margaret R., Nancy L. Saccone, Stephens SH, Ming D. Li, Wang JC, Dale S Cannon, Leena Peltonen, David J Hunter, Angela S. Wenzlaff, Andrew C Heath, Caporaso Neil E., Weiss Robert B., Hoft, Nicole R., Payne Thomas J., Neil E. Caporaso, Keskitalo-Vuokko, Kaisu, Landi, Maria Teresa, Breslau N, Sven Cichon, Xiangyang Kong, Breslau, Naomi, Hoft NR, Rietschel Marcella, Stevens VL, Noethen, Markus M., Nöthen, Markus M., Michele L Pergadia, Heliövaara M, Laura J Bierut, Chatterjee N, Michele L. Pergadia, Susan E Short, Robert C Culverhouse, Ina Giegling, Sun Lingwei, Chen X, Kaprio Jaakko, Jensen MK, Stephens Sarah H., Sherva R, Laura J. Bierut, Chen J, Li MD, Heath AC, Nicole R. Hoft, Majken K Jensen, Broderick P, Stevens Victoria L., Martin Nicholas G., Sherva, Richard, Marcella Rietschel, Aggen SH, Nancy L Saccone, Stephens, Sarah H., Peltonen, Leena, Sreekumar Pillai, Cannon Dale S., Sun, Lingwei, Eisen Tim, Mark F. Leppert, Angela S Wenzlaff, Giegling Ina, Bierut LJ, Heliovaara, Marku, Maria Teresa Landi, Pergadia Michele L., Markku Heliövaara, Hunter DJ, Stevens, Victoria L., Kenneth S Kendler, Keskitalo-Vuokko Kaisu, Cannon, Dale S., Ehringer, Marissa A., Schwantes-An Tae-Hwi, Landi, Maria T., Thomas J. Payne, Li Ming D., Peter Broderick, Montgomery GW, Cichon, Sven, Jingchun Chen, John P Rice, Han Younghun, Wang Jen C., Chen Jingchun, Aggen Steven H., Rujescu D, Nicholas G Martin, Rice John P., Pergadia, Michele L., Jennie Z Ma, Yang Bao-Zhu, Eisen T, Marissa A, Nilanjan Chatterjee, Hunter, David J., Madden Pamela A. F., Victoria L. Stevens, Neil E Caporaso, Sun, Juzhong, Steven H Aggen, Nicholas G. Martin, Kenneth S. Kendler, Chen, Xiangning, Cichon S, Landi Maria Teresa, Joel Gelernter, Mark F Leppert, William Wheeler, Gelemter, Joel, Heliövaara Markku, Kraft Peter, Susan E. Short, Saccone Nancy L., Gelernter Joel, Susan M. Gapstur, Chen, Jingchun, Cichon Sven, Wenzlaff AS, Tim Eisen, Heath Andrew C., Madden PA, Pillai, Sreekumar, Robert C. Culverhouse, Lingwei Sun, Chen Xiangning, Rice, John P., Bao-Zhu Yang, Chatterjee, Nilanjan, Richard Houlston, Kraft, Peter, Majken K. Jensen, Rice JP, Shizhong Han, Nicole R Hoft, Pergadia ML, Saccone, Nancy L., Ming D Li, Han Y, Sherva Richard, Montgomery Grant W., Han S, Culverhouse RC, Victoria L Stevens, Kong Xiangyang, Wheeler W, Pamela A F Madden, Dan Rujescu, Ma JZ, Gapstur SM, Steven H. Aggen, Christopher I. Amos, Wenzlaff Angela S., Schwartz Ann, Caporaso NE, Cannon DS, Hoft Nicole R., Short, Susan E., Tianhua Niu, Jen C. Wang, Eisen, Tim, Leppert MF, Wang Yufei, Niu Tianhua, Caporaso, Neil E., Heath, Andrew C., Kong, Xiangyang, Broderick, Peter, Schwartz, Ann, Juzhong Sun, Wenzlaff, Angela S., Weiss, Robert B., Bierut, Laura J., Peltonen L, Rujescu, Dan, Kong X, Yang, Bao-Zhu, Wang, Yufei, Christopher I Amos, Houlston R, Rujescu Dan, Weiss RB, Susan M Gapstur, Houlston Richard, Rietschel M, Schwantes-An, Tae-Hwi, Leppert, Mark F., Giegling, Ina, Richard Sherva, Montgomery, Grant W., Sun L, Amos CI, Gelernter J, Li, Ming D., Schwantes-An TH, Ehringer MA, Ma, Jennie Z., Sun Juzhong, Wang Y, Sun J, Kendler, Kenneth S., Xiangning Chen, Palotie, Leena, Payne TJ, Tae-Hwi Schwantes-An, Jaakko Kaprio, Nöthen Markus M., Naomi Breslau, Marissa A. Ehringer, Aggen, Steven H., Payne, Thomas J., Robert B, Kraft P, Grant W Montgomery, Margaret R. Spitz, Chatterjee Nilanjan, Spitz Margaret R., Houlston, Richard, Keskitalo-Vuokko K, Ma Jennie Z., David J. Hunter, Niu T, Stephanie H. Witt, Short Susan E., Rietschel, Marcella, Nöthen MM, Schwartz A, Grant W, Pillai Sreekumar, Markus M Nöthen, Pamela A. F. Madden, Han Shizhong, Amos, Christopher I., Giegling I, Dale S. Cannon, Grant W. Montgomery, Jensen Majken K., Spitz MR, Peltonen Leena, Gelernter, Joel, Jennie Z. Ma, Pamela A. F, Short SE, Robert B. Weiss, Madden, Pamela A. F., Ehringer Marissa A., Culverhouse, Robert C, Madden, Pamela A.F, Hunter, David, Jensen, Majken, Heath, Andrew C, Bierut, Laura J, Rice, John P, et al.,, Pergadia, Michele L, Short, Susan, Wang, Jen C, Saccone, Nancy L   +305 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

Journal of Pharmacological Sciences, 2010
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. [PDF]

PLoS ONE, 2013
Crude extracts and three isolated alkaloids from Erythrina mulungu plants have shown anxiolytic effects in different animal models. We investigated whether these alkaloids could affect nicotinic acetylcholine receptors and if they are selective for ...
Pedro Setti-Perdigão, Maria A R Serrano, Otávio A Flausino, Vanderlan S Bolzani, Marília Z P Guimarães, Newton G Castro   +5 more
doaj   +1 more source

Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]

, 2002
Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Modulation of Intestinal Barrier and Bacterial Endotoxin Production Contributes to the Beneficial Effect of Nicotinic Acid on Alcohol-Induced Endotoxemia and Hepatic Inflammation in Rats

Biomolecules, 2015
Alcohol consumption causes nicotinic acid deficiency. The present study was undertaken to determine whether dietary nicotinic acid supplementation provides beneficial effects on alcohol-induced endotoxin signaling and the possible mechanisms at the gut ...
Wei Zhong, Qiong Li, Wenliang Zhang, Qian Sun, Xinguo Sun, Zhanxiang Zhou   +5 more
doaj   +1 more source