Results 31 to 40 of about 156,732 (304)

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

Nicotine's Allure [PDF]

Neuron, 2009
Both conscious and unconscious memory mechanisms contribute to the rewarding effects of nicotine and other drugs of abuse. In this issue of Neuron, Tang and Dani use in vivo measures of synaptic plasticity in freely moving mice to link nicotine-induced dopamine release in hippocampus to LTP induction and behavioral reinforcement.
openaire   +2 more sources

Cholinergic modulation in the vertebrate auditory pathway

Frontiers in Cellular Neuroscience
Acetylcholine (ACh) is a prevalent neurotransmitter throughout the nervous system. In the brain, ACh is widely regarded as a potent neuromodulator. In neurons, ACh signals are conferred through a variety of receptors that influence a broad range of ...
Chao Zhang, R. Michael Burger
doaj   +1 more source

Determination of niacin profiles in some animal and plant based foods by high performance liquid chromatography: association with healthy nutrition

Journal of Animal Science and Technology, 2019
Vitamin B3 (niacin) is essential for all living cells and plays a central role in energy metabolism and oxidative phosphorylation. Vitamin B3, a water-soluble vitamin, is present in the form of nicotinic
Jale Çatak
doaj   +1 more source

Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

Journal of Pharmacological Sciences, 2010
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions [PDF]

, 2003
Background - Antigen-presenting cells (APCs) such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation in the course of adaptive immunity.
Aicher, A, Cooke, JP, Dimmeler, S, Heeschen, C, Mohaupt, M, Zeiher, AM   +5 more
core   +1 more source

Modulation of Intestinal Barrier and Bacterial Endotoxin Production Contributes to the Beneficial Effect of Nicotinic Acid on Alcohol-Induced Endotoxemia and Hepatic Inflammation in Rats

Biomolecules, 2015
Alcohol consumption causes nicotinic acid deficiency. The present study was undertaken to determine whether dietary nicotinic acid supplementation provides beneficial effects on alcohol-induced endotoxin signaling and the possible mechanisms at the gut ...
Wei Zhong, Qiong Li, Wenliang Zhang, Qian Sun, Xinguo Sun, Zhanxiang Zhou   +5 more
doaj   +1 more source

Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. [PDF]

PLoS ONE, 2013
Crude extracts and three isolated alkaloids from Erythrina mulungu plants have shown anxiolytic effects in different animal models. We investigated whether these alkaloids could affect nicotinic acetylcholine receptors and if they are selective for ...
Pedro Setti-Perdigão, Maria A R Serrano, Otávio A Flausino, Vanderlan S Bolzani, Marília Z P Guimarães, Newton G Castro   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source