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Cholinergic receptors and neurodegenerative diseases
Pharmaceutica Acta Helvetiae, 2000Publisher Summary This chapter focuses on cholinergic receptors and neurodegenerative diseases. Known as the “cholinergic hypothesis of Alzheimer's disease (AD),” this hypothesis has served as the main rationale for the development of anti-AD drugs, even if alternative approaches, such as the use of neurotrophic agents, nootropics, glutamate ...
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Cholinergic receptors in insects
Trends in Biochemical Sciences, 1979Abstract It has been suggested that cholinergic receptors in insects are neither nicotinic nor muscarinic but of a mixed nature, and hence differ from ‘classic' vertebrate receptors. However, recent evidence indicates that insects also contain distinct nicotinic and muscarinic binding-sites with properties resembling those of vertebrate receptors. The
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Cholinerge Rezeptoren und Anästhesie
AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie, 1992Postsynaptic chemically controlled ion channels are a possible location for the action of anaesthetics. The nicotinic acetylcholine receptor (AcChoR) is a member of a superfamily of chemically controlled ion channels, which have a large number of structural similarities in common.
Keith W. Miller, Tonner Ph
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Cholinergic Receptor Isolation
1981The isolation of specific cholinergic bindin protein (acetylcholine receptor = AChR) has been achieved successfully by numerous research groups (1-4, 7-9, 11, 12). The ideal source for such preparations was the electric organ of several species of Torpedo.
Peter G. Waser +3 more
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Chapter 5 Cholinergic innervation and receptors in the cerebellum
1997We have studied the source and ultrastructural characteristics of ChAT-immunoreactive fibers in the cerebellum of the rat, and the distribution of muscarinic and nicotinic receptors in the cerebellum of the rat, rabbit, cat and monkey, in order to define which of the cerebellar afferents may use ACh as a neurotransmitter, what target structures are ...
Romeo Caffé +6 more
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Cholinergic receptors in the Aplysia gill
Journal of Neurobiology, 1984AbstractAcetylcholine has been suggested as a neurotransmitter released in the Aplysia gill by peripheral afferents of central neurons and by peripheral neurons within the gill. The perfused gill, isolated from the abdominal ganglion, was examined. At concentrations greater than 1 μM, acetylcholine elicited a slowly developing tonic contraction of the ...
Samuel Weiss +4 more
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The nicotinic cholinergic receptor: A theoretical model
Journal of Neuroscience Research, 1996Based on published affinity-labeling and mutagenesis experiments describing the effect of changes in specific amino acids in molecular biological studies on the nicotinic acetylcholinergic receptor (nAChR), we have identified 12 amino acids which are important in functioning at the nicotinic cholinergic receptor.
Kenny B. Lipkowitz +2 more
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Clinical science, 1984
Muscarinic cholinergic receptors have been identified and characterized by radioligand binding studies in human peripheral lung tissue. The tissue was obtained at thoracotomy of 12 patients, of whom four had chronic obstructive lung disease.
J. Raaijmakers +4 more
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Muscarinic cholinergic receptors have been identified and characterized by radioligand binding studies in human peripheral lung tissue. The tissue was obtained at thoracotomy of 12 patients, of whom four had chronic obstructive lung disease.
J. Raaijmakers +4 more
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Muscarinic cholinergic receptor heterogeneity
Trends in Neurosciences, 1982Abstract The relatively recent application of receptor binding techniques to muscarinic receptor pharmacology has provided new data that generally confirm classical ideas about agonist-receptor interactions and competitive antagonism. However, additional information regarding muscarinic receptor heterogeneity has been provided through [ 3 H]ligand ...
William R. Roeske +2 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues
Journal of Ocular Pharmacology and Therapeutics, 1985Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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