Results 201 to 210 of about 90,058 (326)

From Herbal Tea to Science: Phytochemical and Biological Investigation of Ajuga chamaepitys subsp. chia (Lamiaceae) With Molecular Docking Analysis

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The present study comprehensively investigates the phytochemical profile, biological activities, and molecular docking interactions of Ajuga chamaepitys subsp. chia. Methanolic extracts exhibited notable antioxidant, antidiabetic, and anticholinesterase activities, while germacrene D demonstrated strong multitarget binding affinities in silico.
Bilge Aydın, Amine Sena Aydın, Ömer Çeçen, Hafize Yuca, Gülnur Ekşi Bona, Betül Demirci, Mehmet Bona, Songul Karakaya   +7 more
wiley   +1 more source

Case Report: 2-PAM or not 2-PAM. [PDF]

Clin Pract Cases Emerg Med
Huttner M, Nix K, Blair C, Eisenstat M.
europepmc   +1 more source

First Insights Into the LC‐HRMS Profiling and Biological Activities of Crocus graveolens

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study reports the first comprehensive analysis of Crocus graveolens Boiss. & Reut. using LC‐HRMS, identifying 33 secondary metabolites, with rutin as the major compound (162.808 ± 4.5 μg/g extract). The extract showed moderate antioxidant activity and effectively inhibited acetylcholinesterase (30.88% ± 1.51%) and butyrylcholinesterase (61.22% ± 0.
Ezgi Ersoy, Mehmet Boğa, Alevcan Kaplan, Emel Mataracı Kara, Serpil Demirci Kayıran, Esra Eroğlu Özkan   +5 more
wiley   +1 more source

Efficacy of cholinesterase inhibitors and memantine on symptoms not responsive to levodopa in patients affected by Parkinson's disease without dementia: a systematic review. [PDF]

BMJ Neurol Open
Cani I, Grotteschi N, Calandra-Buonaura G, Guarino M, Guaraldi P, Giannini G, Baldelli L, Donati M, Cortelli P, Camerlingo MD, Nonino F, Sambati L.   +11 more
europepmc   +1 more source

PHARMACOLOGICAL ACTIONS OF INJECTED CHOLINESTERASE* [PDF]

, 1952
I. T. Beck
openalex   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, Volume 25, Issue 15, Page 42-49, August 2025.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Sugammadex versus cholinesterase inhibitors to antagonize respiratory dysfunction after neuromuscular blockade in patients undergoing pulmonary surgery: a systematic review and meta-analysis. [PDF]

Perioper Med (Lond)
Liu B, Song K, Wang P, Li F, Guo Q.
europepmc   +1 more source

Cholinesterases in Human Skin1

, 1955
Olev R Aavik
openalex   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Assessing Diazinon Exposure: A GC-MS/MS Validation Study of BChE Measurement by Point-of-Care Testing and Enzyme Multiplied Immunoassay Technique. [PDF]

Molecules
Hîrjău AC, Crăciun ME, Marandiuc IM, Radu GL.   +3 more
europepmc   +1 more source