Results 21 to 30 of about 1,946 (125)

A glycoproteomic approach to the structural characterization of acidic glycoproteins

, 2009
Glycoproteins, and their subset proteoglycans, are an important group of molecules in joint tissues, providing crucial functions such as cartilage structural integrity and lubrication at cartilage surfaces.
Estrella, Ruby Poblete
core   +1 more source

Accès à l'information biomédicale : vers une approche d'indexation et de recherche d'information conceptuelle basée sur la fusion de ressources termino-ontologiques [PDF]

, 2012
La recherche d'information (RI) est une discipline scientifique qui a pour objectif de produire des solutions permettant de sélectionner à partir de corpus d'information celle qui sont dites pertinentes pour un utilisateur ayant exprimé une requête. Dans
Dinh, Ba-Duy
core  

Development of protein engineered enzymes for the study of galactosaminoglycan neuromedicine [PDF]

, 2006
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006."June 2006."Includes bibliographical references.Glycans are chemically heterogeneous macromolecules that have profound importance in a variety of biological ...
Prabhakar, Vikas
core  

Variations in the chondroitin sulfate-protein linkage region of aggrecans from bovine nasal and human articular cartilages

, 1996
Aggrecan-derived chondroitin sulfate (CS) chains, released by beta-elimination, were derivatized with p-aminobenzoic acid or p-aminophenol; radioiodinated; and subjected to graded or complete degradations by chondroitin ABC lyase to generate linkage ...
Anson, Bayliss, Bayliss, Bernfield, Cheng, Cheng, David, de Waard, Fransson, Fransson, Fransson, Habuchi, Heinegård, Heinegård, Kaplan, Karamanos, Kjellén, Laine, Liu, Ludwigs, Mathews, Oegema, Ototani, Rodén, Rodén, Shibata, Sugahara, Sugahara, Sugahara, Suzuki, Yamada, Yamada, Yoshida   +32 more
core   +1 more source

Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry

Molecular Genetics and Metabolism Reports, 2017
Mucopolysaccharidosis (MPS) is a genetic disorder characterized by the accumulation of glycosaminoglycans in the body. Of the multiple MPS disease subtypes, several are caused by defects in sulfatases.
R. Mashima, Mari Ohira, T. Okuyama, Akiya Tatsumi   +3 more
semanticscholar   +1 more source

Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6months of therapy in cats using different IV infusion durations.

Molecular Genetics and Metabolism, 2016
BACKGROUND Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease characterized by an absence or marked reduction of lysosomal N-acetylgalactosamine-4-sulfatase activity.
Therese Ruane, M. Haskins, Alphonsus Cheng, Ping Wang, G. Aguirre, V. Knox, Yulan Qi, T. Tompkins, Charles A. O’Neill   +8 more
semanticscholar   +1 more source

Deletion of exon 4 in the N-acetylgalactosamine-4-sulfatase gene in a Taiwanese patient with mucopolysaccharidosis type VI.

Tohoku journal of experimental medicine, 2015
Mucopolysaccharidosis type VI (MPS VI) is a rare autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-4-sulfatase (ARSB), one of the enzymes required for the degradation of dermatan sulfate (DS).
Wei-De Lin, Y. Ke, I. Chou, C. Wang, F. Tsai   +4 more
semanticscholar   +1 more source

Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase): Potential Role as a Biomarker in Prostate Cancer

Prostate Cancer and Prostatic Diseases, 2013
Background:The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.Methods:ARSB ...
L. Feferman, S. Bhattacharyya, Ryan J. Deaton, P. Gann, Guzmán, A. Kajdacsy-Balla, J. Tobacman   +6 more
semanticscholar   +1 more source

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

Signal Transduction and Targeted Therapy
Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB).
S. Bhattacharyya, J. Tobacman
semanticscholar   +1 more source

N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism

International Journal of Molecular Sciences
The effects of the enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B, ARSB), which removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate, on the expression of PD-L1 were determined, and the underlying mechanism of PD-L1 ...
S. Bhattacharyya, I. O-Sullivan, J. Tobacman   +2 more
semanticscholar   +1 more source