Results 141 to 150 of about 213,570 (404)

Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats. [PDF]

, 2006
Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth ...
Abe, Nobuhiro, Doi, Hideyuki, Kitamura, Ai, Komiyama, Takamitsu, Miyazawa, Shinichi, Nasu, Yoshihisa, Nishida, Keiichiro, Ozaki, Toshifumi, Yorimitsu, Masanori, Yoshida, Aki   +9 more
core   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

Cell-based Approaches to Joint Surface Repair : A Research Perspective [PDF]

, 2013
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050). None of the authors received any funding related to the writing of this manuscript, and the funding bodies did not play any role in the
A.J. Roelofs, Alegre-Aguaron, Augello, Barbero, Bentley, Bentley, Boneberg, Bos, Boxall, Brittberg, Buckwalter, C. De Bari, Centeno, Cole, Da Silva, De Bari, De Bari, De Bari, De Bari, Dell'Accio, Dell'Accio, Dominici, Dowthwaite, Eltawil, Farrell, Frank, Friedenstein, Gelber, Gilbert, Gomoll, Hangody, Hennig, Huang, Huang, J.P.J. Rocke, Jacobi, Jiang, Johnson, Jones, Kafienah, Karystinou, Khan, Kim, Knutsen, Knutsen, Koga, Koga, Koshino, Kreuz, Kuroda, Kuroda, Kurth, Lee, Magnussen, Maijenburg, Marsano, Mauck, Mendez-Ferrer, Minas, Mochizuki, Muraglia, Murata, Murphy, Nakahara, Nejadnik, Pabbruwe, Park, Pelttari, Peterson, Peterson, Pittenger, Prockop, Qiu, Quirici, Roberts, Roberts, Sacchetti, Sakaguchi, Saris, Saris, Schnabel, Scotti, Sekiya, Shirasawa, Silverman, Steadman, Studer, Takahashi, Tasso, Ter Huurne, Tormin, Van de Breevaart, Vanlauwe, Vinardell, Von der Mark, Wakitani, Wakitani, Wakitani, Wei, Williams, Yoshimura, Zhang, Zhang, Zuk   +103 more
core   +1 more source

A Poroelastic Mixture Model of Mechanobiological Processes in Tissue Engineering. Part I: Mathematical Formulation [PDF]

arXiv, 2015
An adequate control of cell response in tissue engineering applications is of utmost importance to obtain products suitable to clinical practice. This paper is the first part of a series of two connected publications in which we study via mathematical tools the cultivation in bioreactors of articular chondrocytes.
arxiv  

Gene Delivery to Chondrocytes

, 2023
AbstractDelivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different viral and non-viral vectors for this purpose.
Christopher V, Nagelli, Christopher H, Evans, Rodolfo E, De la Vega   +2 more
openaire   +2 more sources

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]

, 2009
Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul, Hendren, Linda, The University of Northampton   +2 more
core   +1 more source

Investigation of high frequency transducers and coded signals suitable for cartilage volume imaging [PDF]

arXiv, 2019
Cartilage degeneration in joints causing pain and various types of knee problems is a serious problem-affecting people in all ages. Degenerated articular cartilage is also known as a central hallmark of osteoarthritis, which is a complex musculoskeletal disorder involving numerous contributory genetic, constitutional and biomechanical factors.
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells.

Tissue engineering. Part B, Reviews, 2014
Articular cartilage exhibits an inherently low rate of regeneration. Consequently, damage to articular cartilage often requires surgical intervention.
K. Hubka, R. Dahlin, V. Meretoja, F. Kasper, A. Mikos   +4 more
semanticscholar   +1 more source