Results 181 to 190 of about 101,193 (316)

Matching TGF‐β1 Activation With Stress‐Responsive Charge‐Reversal Hydrogel Microspheres for the Treatment of Osteoarthritis

Exploration, EarlyView.
Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin, Yiwen Xu, Lei Xiang, Yueliang Zhu, Yihan Li, Yaping Zhuang, Zengjie Zhang, Jiayu Chen, Heemin Kang, Ning Zhang, Xiaohua Yu, Wenguo Cui   +11 more
wiley   +1 more source

DCLK1-dependent NF-κB activation mediates p-STAT3-induced osteoarthritis progression. [PDF]

Clin Transl Med
Li P, Wong C, Wang Y, Liang T, Que Y, Gao W, Liu Y, Gao B.   +7 more
europepmc   +1 more source

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

Long-term expandable auricular chondrocytes reveal a conserved nine-gene decline module underlying senescence-independent dedifferentiation. [PDF]

Regen Ther
Alemujiang D, Tsuji N, Sakamoto T, Chu YY, Hoshi K, Hikita A.   +5 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway. [PDF]

Mol Med Rep
Adam MS, Zhuang H, Ren X, Zhang Y, Zhou P.   +4 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

The transcriptional atlas, intercellular communication, and metabolic reprogramming of the cartilage and synovium in osteoarthritis patients with diabetes mellitus : a multiomics study. [PDF]

Bone Joint Res
Wen Y, Liu S, Chen H, Tu M, Zhao D, Xing J, Zheng W, Zhong Y, Wang H, Chen L.   +9 more
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

DHA-Derived Lipid Mediators Attenuate Osteoarthritis by Resolving Inflammation and Protecting Cartilage in Association with the SIRT1 Signaling Pathway. [PDF]

Mar Drugs
Su Y, Kwon SK, Choi HS, Han Y, Park JH, Choi JH, Seo JW.   +6 more
europepmc   +1 more source