Multi‐Scale Analysis of Regional Pathology in the Human Trapezium During Osteoarthritis Progression
ABSTRACT Trapeziometacarpal (TMC) osteoarthritis (OA) is a prevalent condition that significantly impacts hand function and quality of life. In this study we sought to close gaps in knowledge related to the initiation and progression of TMC OA on the tissue scale by evaluating the morphology and gross appearance, wear patterns, mechanical properties ...
Brendan D. Stoeckl+5 more
wiley +1 more source
Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype. [PDF]
Ditchfield C+3 more
europepmc +1 more source
Changes in parathyroid hormone receptors during chondrocyte cytodifferentiation.
Masahiro Iwamoto+9 more
openalex +1 more source
In Vitro Evaluation of Hemiarthroplasty Bearing Materials: A Scoping Review (Part I)
ABSTRACT Hemiarthroplasty is used to treat joint damage confined to one side, aiming to preserve the remaining healthy cartilage and bone while addressing conditions like femur fractures and osteonecrosis; however, challenges persist due to cartilage wear and inconsistent clinical outcomes.
Victoria P. Marino+6 more
wiley +1 more source
Cellular Senescence in Human Chondrocytes in Relation to Osteoarthritis. [PDF]
Qiang Y+8 more
europepmc +1 more source
A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice
ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka+8 more
wiley +1 more source
Repetitive Compressive Loading Downregulates Mitochondria Function and Upregulates the Cartilage Matrix Degrading Enzyme MMP-13 Through the Coactivation of NAD-Dependent Sirtuin 1 and Runx2 in Osteoarthritic Chondrocytes. [PDF]
Takemoto M+5 more
europepmc +1 more source
ABSTRACT Osteoarthritis (OA) is a common degenerative osteoarthropathy with an unclear pathogenesis. Circular RNA (circRNA) has been reported to be associated with OA progression. This study aims to explore the role and potential mechanism of hsa_circ_0006646 in OA. Interleukin‐1β (IL‐1β)‐induced human chondrocytes were used as the cell model of OA. RT‐
Ming‐Yu Hua+3 more
wiley +1 more source