Results 331 to 340 of about 214,417 (382)

Mechanism of EC‐EXOs‐Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss

Cell Proliferation, EarlyView.
EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang, Zhaokai Zhou, Wenjie Chen, Yun Chen, Qiyue Zheng, Yajun Chen, Zhengxiao Ouyang, Ran Xu, Qiong Lu   +8 more
wiley   +1 more source

Primary cilia and inflammatory response: unveiling new mechanisms in osteoarthritis progression. [PDF]

Exp Biol Med (Maywood)
Sun Y, Luo Z, Fu Y, Ngo T, Wang W, Wang Y, Kong Y.   +6 more
europepmc   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

The mitochondrial protectant SS31 optimized decellularized Wharton's jelly scaffold improves allogeneic chondrocyte implantation-mediated articular cartilage repair. [PDF]

J Orthop Translat
Wang C, Li H, Li F, Yang Y, Xu Z, Gao T, Li R, Zhang R, Mu Y, Guo Z, Guo Q, Liu S.   +11 more
europepmc   +1 more source

Considerations and challenges of septic arthritis and osteomyelitis

Equine Veterinary Education, EarlyView.
Summary Septic arthritis remains a common orthopaedic condition in both human and veterinary medicine which can cause serious morbidity and pose considerable challenges for clinical management. The majority of the published clinical research in humans and veterinary species has been focused on the diagnosis, treatment, prevention and outcome of this ...
J. B. Engiles, H. L. Stewart
wiley   +1 more source

Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research. [PDF]

J Transl Med
Wang Y, Kong Y, Du J, Qi L, Liu M, Xie S, Hao J, Li M, Cao S, Cui H, Liu A, Ma J, Song Y.   +12 more
europepmc   +1 more source

Exploring the role of directly coupled alternating electric fields on chondrocyte morphology and redifferentiation capacity with a focus on sex differences. [PDF]

J Exp Orthop
Song Z, Freiin Grote V, Sahm F, Zimmermann J, Lutter C, Jonitz-Heincke A, Bader R.   +6 more
europepmc   +1 more source

Adaptive hydrogel loaded with pre-coordinated stem cells for enhanced osteoarthritis therapy. [PDF]

Bioact Mater
Gao C, Dai W, Liu D, Wang X, Zhang T, Yu B, Yu Y, Tian H, Yang X, Cai Q.   +9 more
europepmc   +1 more source

SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis. [PDF]

Bone Res
Zu X, Chen S, Li Z, Hao L, Fu W, Zhang H, Yin Z, Wang Y, Wang J.   +8 more
europepmc   +1 more source

FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release. [PDF]

Int J Mol Sci
Chen X, Liu H, Huang Y, Li L, Jiang X, Liu B, Li N, Zhu L, Liu C, Xiao J.   +9 more
europepmc   +1 more source