Results 341 to 350 of about 231,673 (393)

Autologous Chondrocyte Implantation

The Journal of Bone & Joint Surgery, 2006
Injuries to joint surfaces can result from acute high-impact or repetitive shear and torsional loads to the superficial zone of the articular cartilage architecture. The use of autologous chondrocyte implantation is promising and is associated with several potential long-term benefits.
Jones, D. G., Peterson, L.
openaire   +3 more sources

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes.

Biomaterials, 2018
Cartilage lesions in degenerative osteoarthritis (OA) are involved with pathological microenvironmental alterations induced by inflammatory macrophages, and apoptotic and/or hypertrophic chondrocytes.
Meilu Dai, Baiyan Sui, Yang Xue, Xin Liu, Jiao Sun   +4 more
semanticscholar   +1 more source

Molecular characterisation of chondrocytes in autologous chondrocyte implantation

International Journal of Molecular Medicine, 2004
Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the apoptotic index of cells implanted ...
M H, Zheng, E, King, Y, Kirilak, L, Huang, J M, Papadimitriou, D J, Wood, J, Xu   +6 more
openaire   +2 more sources

Autologous chondrocyte transplantation

Operative Techniques in Sports Medicine, 2000
Since its introduction in 1987, autologous chondrocyte transplantation (ACT) for the management of full-thickness chondral defects of the knee has gained considerable attention and has renewed interest in cartilage repair. At this time there are patients with 10 to 13 years of follow-up who have continued to benefit from ACT.
Tom Minas, Lars Peterson
openaire   +1 more source

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

Annals of the New York Academy of Sciences, 2018
Articular chondrocytes are quiescent, fully differentiated cells responsible for the homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine‐tuned balance between anabolic and catabolic functions.
Purva Singh, K. Marcu, M. Goldring, M. Otero   +3 more
semanticscholar   +1 more source

Catering to chondrocytes

Science Translational Medicine, 2018
An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al ., this issue).
openaire   +2 more sources

Autologous Chondrocyte Transplantation

Clinical Orthopaedics and Related Research, 1999
The intrinsic capacity of cartilage to repair chondral injuries is poor. Different techniques to induce cartilage repair with the use of extrinsic chondrogeneic cell sources have been explored in experimental models. Cells can be harvested autologously or as allografts from a healthy part of the donor tissue, isolated, expanded in vitro, and finally ...
openaire   +2 more sources

Chondrocyte Isolation and Expansion

2022
Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small clusters, over a period of a few days in monolayer culture.
Paul, Harrison, Timothy, Hopkins, Charlotte, Hulme, Helen, McCarthy, Karina, Wright   +4 more
openaire   +2 more sources

In situ chondrocyte viscoelasticity

Journal of Biomechanics, 2012
It has been proposed, based on theoretical considerations, that the strain rate-dependent viscoelastic response of cartilage reduces local tissue and cell deformations during cyclic compressions. However, experimental studies have not addressed the in situ viscoelastic response of chondrocytes under static and dynamic loading conditions. In particular,
Sang-Kuy, Han, Ryan, Madden, Ziad, Abusara, Walter, Herzog   +3 more
openaire   +2 more sources

Prevention of Chondrocyte Apoptosis

The Journal of Bone and Joint Surgery-American Volume, 2001
The occurrence of chondrocyte apoptosis may be cri­tical in determining the extent of a lesion and sub­sequent repair after mechanical injury to articular cartilage. Agents that prevent apoptosis and increase chondrocyte survival may prove beneficial in the treatment of these ­lesions.
D D, D'Lima, S, Hashimoto, P C, Chen, M K, Lotz, C W, Colwell   +4 more
openaire   +2 more sources