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Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes.

ACS Nano, 2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (
Hongfu Cao   +9 more
semanticscholar   +1 more source

Mechanical confinement regulates cartilage matrix formation by chondrocytes

open access: yesNature Materials, 2017
Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.
Hong-Pyo Lee, Luo Gu, David J Mooney
exaly   +2 more sources

The chondrocyte

The International Journal of Biochemistry & Cell Biology, 2003
The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement.
Archer, C W, Francis-West, P
openaire   +3 more sources

Chondrocyte transplantation

Arthroscopy: The Journal of Arthroscopic & Related Surgery, 1996
The transplantation of chondrocytes as a treatment to repair defects and degeneration in hyaline articular cartilage is being tested in numerous laboratory and clinical settings. This has included transplanting chondrocytes grown in tissue culture that were procured from non-weight-bearing areas of the affected joint to transplanting allografts with ...
D W, Jackson, T M, Simon
openaire   +2 more sources

Interleukin-1β signaling in osteoarthritis - chondrocytes in focus.

Cellular Signalling, 2019
Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that affects all tissues of a joint and one of the major endpoints being loss of articular cartilage.
Z. Jenei-Lanzl, A. Meurer, F. Zaucke
semanticscholar   +1 more source

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.

Free Radical Biology & Medicine, 2019
Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the degeneration and destruction of the articular cartilage.
Yue Hu   +5 more
semanticscholar   +1 more source

Chondrocyte Differentiation

1995
Data obtained while investigating growth plate chondrocyte differentiation during endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis depends on positional signaling mediated by selected homeobox-containing genes and soluble mediators.
R, Cancedda   +2 more
openaire   +2 more sources

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