Results 201 to 210 of about 21,815 (286)
CHONDROITIN, A NEW MUCOPOLYSACCHARIDE
Journal of Biological Chemistry, 1954 E A, DAVIDSON, K, MEYER
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JOR SPINE, Volume 9, Issue 2, June 2026.The intervertebral discs (IVDs) from mice with amyloid pathologies are larger, flatter, and exhibit increased energy absorption, making these IVDs more susceptible to damage. This heightened vulnerability may predispose elderly individuals with AD to disc injuries, accelerating IVD degeneration and spinal pain. ABSTRACT Background Chronic low back pain,
C. E. Gonzalez +5 more
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JOR SPINE, Volume 9, Issue 2, June 2026.Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody +4 more
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Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design [PDF]
Miao Tian +6 more
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JOR SPINE, Volume 9, Issue 2, June 2026.Low‐magnitude high‐frequency vibration (LMHFV), with or without 17β‐oestradiol (E2), exacerbated papain‐induced bovine intervertebral disc degeneration, reducing cell viability, impairing matrix production, and increasing inflammation. E2 showed no protective effect against papain‐induced degeneration or LMHFV.
Jan Ulrich Jansen +9 more
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JOR SPINE, Volume 9, Issue 2, June 2026.Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill +7 more
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Innovative Drug Delivery Systems for the Treatment of Glaucoma
MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu +9 more
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CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. [PDF]
, 1996 Craig A. Henke +4 more
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MedComm – Oncology, Volume 5, Issue 2, June 2026.CD44‐targeted CNPs co‐deliver Zn2+ and MIT–ALA to CRC cells. Intracellularly, Zn2+ inhibits GLUT1‐dependent glycolysis, and ALA disrupts mitochondrial function, driving metabolic exhaustion in CSCs. This mitochondrial damage primes GSDMD‐mediated pyroptosis, accompanied by the release of pro‐inflammatory cytokines (IL‑1β, IL‑18).
Qinxia Chang +8 more
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