Results 101 to 110 of about 435,081 (300)

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice

Glia, EarlyView.
Newly generated myelinating oligodendrocyte accumulation is decreased in the corpus callosum of aged mice. Morphological changes of newly generated myelinating oligodendrocytes in aged mice: greater height, shorter, and fewer myelin sheaths. ABSTRACT The activity of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) throughout life ...
Sasikarn Looprasertkul, Reiji Yamazaki, Yasuyuki Osanai, Nobuhiko Ohno   +3 more
wiley   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Changes in synovial fluid biomarkers and clinical efficacy of intra‐articular injections of hyaluronic acid for patients with knee osteoarthritis

Journal of Experimental Orthopaedics, 2014
Background The changes in synovial fluid biomarkers after intra‐articular injection of hyarulonic acid (IA HA) remain controversial. We investigate the changes in the properties of synovial fluid (SF) and clinical symptoms before the first and fifth IA ...
Yoshihiro Kusayama, Yasushi Akamatsu, Ken Kumagai, Hideo Kobayashi, Masato Aratake, Tomoyuki Saito   +5 more
doaj   +1 more source

NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans

Nature Neuroscience, 2012
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury.
Travis L. Dickendesher, Katherine T. Baldwin, Yevgeniya A. Mironova, Y. Koriyama, Stephen J Raiker, Kim L. Askew, A. Wood, Cédric G. Geoffroy, B. Zheng, Claire D. Liepmann, Y. Katagiri, L. Benowitz, H. M. Geller, R. Giger   +13 more
semanticscholar   +1 more source

Generation and functional analysis of melanoma antigen‐specific CD8+ T cells derived from S/MAR vector‐transfected human induced pluripotent stem cells

International Journal of Cancer, EarlyView.
What's New? Adoptive cell therapy (ACT) with tumor antigen‐specific CD8+ T cells has shown success in clinical trials treating patients with advanced or metastatic melanoma. Here, the authors established protocols for generating CD8+ T cells from human induced pluripotent stem cells (hiPSCs) expressing a melanoma‐specific T cell receptor (TCR) or ...
Juliane Poelchen, Sandra Pardo, Daniel Novak, Qian Sun, Tamara Steinfass, Marlene Vierthaler, Özge Cicek Sener, Karol Granados Blanco, Yiman Wang, Jan Peter Nicolay, Pierre Guermonprez, Richard Harbottle, Viktor Umansky, Jochen Utikal   +13 more
wiley   +1 more source

Immunostimulatory Activity of Tilapia-head Chondroitin Sulfate in RAW 264.7 Cells and Mice

Shipin gongye ke-ji
In this study, RAW 264.7 cells and immunosuppressive models were used to investigate the immunostimulatory activity of tilapia-head chondroitin sulfate (CS) through in vitro and in vivo experiments.
Houpei HUANG, Yuan YUAN, Zhuo WANG, Jing CHEN, Bingbing SONG, Saiyi ZHONG   +5 more
doaj   +1 more source

DEGRADATION OF CHONDROITIN SULFATE BY PROTEUS VULGARIS [PDF]

, 1959
Rafael J. Martinez, Jack B. Wolfe, Henry I. Nakada   +2 more
openalex   +1 more source

Biological functions of iduronic acid in chondroitin/dermatan sulfate

The FEBS Journal, 2013
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides because it generates a more flexible chain with increased binding potentials.
M. A. Thelin, B. Bartolini, J. Axelsson, R. Gustafsson, E. Tykesson, E. Pera, A. Oldberg, M. Maccarana, A. Malmstrom   +8 more
semanticscholar   +1 more source

Development of a Decellularized Urinary Bladder Matrix and Heparin‐Based Cryogel for Promoting Angiogenesis

Macromolecular Bioscience, EarlyView.
A dECM‐based cryogel scaffold with sustained VEGF release is developed to promote angiogenesis in ischemic tissues. Fabricated from decellularized porcine urinary bladder matrix and heparin, the scaffold supports VEGF binding and prolonged release. The cryogel demonstrates enhanced angiogenic potential in vitro and in a murine hindlimb ischemia model ...
Dayeon Roo, Minkyu Lee, Sivashanmugam Amirthalingam, Kyung Min Ryu, Beom Seok Kim, Juan M. Melero‐Martin, Kyoung‐Ha So, Nathaniel S. Hwang   +7 more
wiley   +1 more source