Experimental Physiology, EarlyView.Abstract Knee osteoarthritis is experienced by hundreds of millions of people worldwide and is a major cause of disability. Although enhancing physical activity levels and the participation in exercise programmes has been proved to improve the debilitating illness of osteoarthritis, many do not engage in recommended levels of physical activity.
Karl Morgan +3 more
wiley +1 more source
Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration
JOR SPINE, Volume 9, Issue 1, March 2026.This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump +8 more
wiley +1 more source
Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity. [PDF]
J Biol Chem, 2014 Panagos CG +14 more
europepmc +1 more source
JOR SPINE, Volume 9, Issue 1, March 2026.Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson +5 more
wiley +1 more source
Variants ofPlasmodium falciparumErythrocyte Membrane Protein 1 Expressed by Different Placental Parasites are Closely Related and Adhere to Chondroitin Sulfate A [PDF]
, 2001 Ayman Khattab +4 more
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In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 838-852, March 2026.ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini +5 more
wiley +1 more source
Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis. [PDF]
Int J Mol Sci, 2016 Li L +7 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán +7 more
wiley +1 more source
CANT1 Is Involved in Collagen Fibrogenesis in Tendons by Regulating the Synthesis of Dermatan/Chondroitin Sulfate Attached to the Decorin Core Protein [PDF]
Rina Yamashita +8 more
openalex +1 more source