Results 81 to 90 of about 11,136 (271)

Chondroitin 4-Sulfate Disaccharide-Based Inhibitors of Cathepsin S

Polysaccharides
Cathepsin S (Cat S) is a cysteine protease involved in several human diseases (i.e., autoimmune, inflammatory and cardiovascular disorders, cancer, and psoriasis) and is an important target in drug development.
Alexis David, Roxane Domain, Florian Surback, Aude Vibert, Pierre Buisson, Martyna Maszota-Zieleniak, Ludovic Landemarre, Marie Schuler, Gilles Lalmanach, Sergey A. Samsonov, Chrystel Lopin-Bon, Fabien Lecaille   +11 more
doaj   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication

Frontiers in Integrative Neuroscience, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Heleen M. van 't Spijker, Jessica C. F. Kwok, Jessica C. F. Kwok   +2 more
doaj   +1 more source

Isolation and Chemical Characterization of Chondroitin Sulfate from Cartilage By-Products of Blackmouth Catshark (Galeus melastomus) [PDF]

, 2018
José Antonio Vázquez, Javier Fraguas, Ramón Novoa-Carballal, Rui L. Reis, Luís T. Antelo, Ricardo I. Pérez‐Martín, Jesús Valcárcel   +6 more
openalex   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Microbiological-Chemical Sourced Chondroitin Sulfates Protect Neuroblastoma SH-SY5Y Cells against Oxidative Stress and Are Suitable for Hydrogel-Based Controlled Release. [PDF]

Antioxidants (Basel), 2021
Bedini E, Iadonisi A, Schiraldi C, Colombo L, Albani D, Petrini P, Giordano C, Tunesi M.   +7 more
europepmc   +1 more source

The Binding of Chondroitin Sulfate to Pleiotrophin/Heparin-binding Growth-associated Molecule Is Regulated by Chain Length and Oversulfated Structures [PDF]

, 2005
Nobuaki Maeda, Nobuna Fukazawa, Toshihiro Hata   +2 more
openalex   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons [PDF]

, 2023
Eleonora Bianchi, Marco Ruggeri, Barbara Vigani, Elena Del Favero, Caterina Ricci, Cinzia Boselli, Antonia Icaro Cornaglia, César Viseras, Silvia Rossi, Giuseppina Sandri   +9 more
openalex   +1 more source

Comparison between dispersive hidroxypropylmethylcellulose and sodium hyaluronate in phacoemulsification: a systematic review and meta-analysis [PDF]

Revista Brasileira de Oftalmologia
Background: There is a debate regarding the differences in intraocular pressure values between different types of dispersive ophthalmic viscosurgical devices in patients after phacoemulsification for cataracts.
Francisco Victor Carvalho Barroso, Dillan Cunha Amaral, Samuel Montenegro Pereira, David Rocha Lucena, Ricardo Noguera Louzada   +4 more
doaj   +1 more source

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

Arthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H.W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source