Results 31 to 40 of about 56,482 (307)

Is Chemotherapy Associated with Improved Overall Survival in Patients with Dedifferentiated Chondrosarcoma? A SEER Database Analysis

Clinical Orthopaedics and Related Research, 2021
Background Dedifferentiated chondrosarcoma is a chondrosarcoma subtype associated with high rates of recurrence and a poor prognosis. Others have proposed treatment of dedifferentiated chondrosarcoma using osteosarcoma protocols, including perioperative ...
L. Cranmer, Bonny Chau, J. Mantilla, E. Loggers, S. Pollack, Teresa S. Kim, Edward Y. Kim, G. Kane, Matthew J. Thompson, Jared L. Harwood, M. Wagner   +10 more
semanticscholar   +1 more source

Osteoblastoma in the occipital bone: A case report of a rare tumor in the calvarium [PDF]

, 2020
Osteoblastomas infrequently occur in the calvarium, displaying a preference for temporal and frontal bones when it does. We present an unusual case of a large, expansile osteoblastoma in the occipital bone of a 23-year-old man who presented with a ...
Faro, Scott H., Gorniak, Richard J., Trunz, Lukas M.   +2 more
core   +2 more sources

Metabolic Pathways and Targets in Chondrosarcoma

Frontiers in Oncology, 2021
Chondrosarcomas are the second most common primary bone malignancy. Chondrosarcomas are characterized by the production of cartilaginous matrix and are generally resistant to radiation and chemotherapy and the outcomes are overall poor.
I. Micaily, Megan E Roche, Mohammad Y. Ibrahim, U. Martinez-Outschoorn, A. Mallick   +4 more
semanticscholar   +1 more source

Physical Function and Quality of Life After Resection of Mobile Spine Chondrosarcoma. [PDF]

, 2019
Study Design:Retrospective cohort study. Objectives:(1) To assess patient-reported outcomes-physical function, pain, and quality of life-in patients who underwent resection of a mobile spine chondrosarcoma.
Chen, Yen-Lin E, DeLaney, Thomas F, Hartveldt, Stefan, Hornicek, Francis J, Janssen, Stein J, Paulino Pereira, Nuno Rui, Schwab, Joseph H, Stoop, Nicky   +7 more
core   +1 more source

The treatment of primary tumors of the femur with chemotherapy (if indicated), resection and reconstruction with an endoprosthesis [PDF]

, 1985
The treatment protocol of 15 patients with a primary tumor of the femur, including osteosarcoma, malignant fibrous histiocytoma and chondrosar-coma is presented. All patients had been selected for resection and reconstruction with an endoprosthesis.
Göeken, L.N.H., Hartel, R.M., Heeten, G.J. den, Kamps, W., Krieken, F. van, Nielsen, H.K.L., Oldhoff, J., Oosterhuis, J.W., Postma, A., Schraffordt Koops, H., Veth, R.P.H.   +10 more
core   +5 more sources

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis [PDF]

, 2016
Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components.
Cao, Dengfeng, Chen, Rongrong, Chen, Xi, DeLaney, Thomas F, Gao, Lu, Gao, Xiaohuan, Gong, Xinqi, Guo, Xiaopeng, Hong, Xiafei, Ni, Jianjiao, Tian, Pangzehuan, Wang, Renzhi, Xing, Bing, Yao, Yong   +13 more
core   +2 more sources

Gadd45β expression in chondrosarcoma: A pilot study for diagnostic and biological implications in histological grading

Diagnostic Pathology, 2010
Background Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very ...
Ishido Yasuhiro, Yamamoto Takuya, Nagano Satoshi, Yokouchi Masahiro, Sakakima Harutoshi, Tanimoto Akihide, Zenmyo Michihisa, Komiya Setsuro, Ijiri Kosei   +8 more
doaj   +1 more source

Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated.
Changbao Chen, Hua Zhou, Xiaolin Zhang, Xinlong Ma, Zhongjun Liu, Xiaoguang Liu   +5 more
doaj   +1 more source

Chondrosarcoma of the Thorax [PDF]

Sarcoma, 2011
Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum,
W. Roy Smythe, Scott I. Reznik, Philip A. Rascoe   +2 more
openaire   +2 more sources

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

Molecular Cancer, 2010
Background Chondrosarcoma is a disease that does not respond to conventional cytotoxic chemotherapy and expression of MMP1 is a marker for a poor prognosis. The mechanism of increased MMP1 expression in chondrosarcoma is not completely known. Our goal is
Chen Qian, Wei Lei, Sun Xiaojuan, Terek Richard M   +3 more
doaj   +1 more source