Results 51 to 60 of about 7,866 (268)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

A Low Noise Multipath Chopper-Stabilized Operational Amplifier Using Dynamic Element Matching Gain-Boosting and Low Input Current Adaptive Clock-Boosting Chopper Switch

IEEE Access
This paper presents a low noise multipath operational amplifier with chopper-stabilized and gain-boosted low-frequency path (LFP) amplifier. The LFP amplifier adopts the gain-boosting using dynamic element matching (DEM) and buffered adaptive clock ...
Mookyoung Yoo, Gibae Nam, Minhyeok Son, Manhyuck Choi, Inju Yu, Dahyun Jin, Euiyoung Lee, Hajun Bin, Hyoungho Ko   +8 more
doaj   +1 more source

Green-pumped, picosecond MgO:PPLN optical parametric oscillator

, 2011
We investigate the performance of a magnesium-oxide-doped periodically poled lithium niobate crystal (MgO:PPLN) in an optical parametric oscillator (OPO) synchronously-pumped by 530nm, 20ps, 230MHz pulses with an average power of up to 2W from a ...
Alam, Shaif-ul, Gawith, Corin B.E., Hung, Hazel, Kienle, Florian, Lin, Dejiao, Major, Huw, Richardson, David J., Shepherd, David P.   +7 more
core   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Network of Time-Multiplexed Optical Parametric Oscillators as a Coherent Ising Machine [PDF]

, 2014
Finding the ground states of the Ising Hamiltonian [1] maps to various combinatorial optimization problems in biology, medicine, wireless communications, artificial intelligence, and social network.
Byer, Robert L., Marandi, Alireza, Takata, Kenta, Wang, Zhe, Yamamoto, Yoshihisa   +4 more
core   +3 more sources

Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement

Advanced Science, EarlyView.
The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang, Xinyuan Ke, Andrew Heath, Richard J. Ball, Jiawei Xie, Jinchen Fan, Guisheng Li, Kevin Paine   +7 more
wiley   +1 more source

An intensity-modulated dual-wavelength He-Ne laser for remote sensing of methane [PDF]

, 1986
A new type of dual wavelength He-Ne laser is described in which the output power at each of the two wavelengths is modulated with equal amplitude and opposite phase to each other.
posed., Uehara, K.
core   +1 more source

Mapping the CMB I: the first flight of the QMAP experiment

, 1998
We report on the first flight of the balloon-borne QMAP experiment. The experiment is designed to make a map of the cosmic microwave background anisotropy on angular scales from 0.7 to several degrees.
Amber D. Miller, Angelica de Oliveira-Costa, Bennett C. L., C. Barth Netterfield, Lyman A. Page, Mark J. Devlin, Max Tegmark, Tom Herbig   +7 more
core   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source