Results 101 to 110 of about 16,071 (223)

Ubiquitin-independent pathway regulates the RIT1-MAPK pathway in chordoma progression

Cell Death and Disease
Chordoma is a rare, slow-growing malignant tumor originating from embryonic notochord remnants and is often found in the sacrum or skull base. It is categorized into conventional, poorly differentiated, and dedifferentiated types, with the conventional ...
Hui Chen, Qiujing Guan, Cheng Yang, Yang Chen, Yan Liu, Wenjie Ren, Su Chen, Lei Li, Dongxia Li, Jianguo Tang, Nanzhe Zhong   +10 more
doaj   +1 more source

Chordoma of the Oropharynx

Medical Archives
Background: Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of „NOS“ chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient.
Ramas, Almedina, Kasumovic, Merima, Uscupsic, Sabrina, Mujic, Majda, Tokic, Lejla   +4 more
openaire   +2 more sources

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Nature Communications, 2019
Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (n = 11) may be characterized by genomic patterns indicative of defective ...
S. Gröschel, Daniel Hübschmann, Francesco Raimondi, P. Horák, Gregor Warsow, M. Fröhlich, B. Klink, L. Gieldon, B. Hutter, K. Kleinheinz, D. Bonekamp, O. Marschal, Priya Chudasama, Jagoda Mika, Marie Groth, S. Uhrig, Stephen Krämer, C. Heining, C. Heilig, D. Richter, E. Reisinger, K. Pfütze, R. Eils, S. Wolf, C. von Kalle, C. Brandts, C. Scholl, W. Weichert, S. Richter, S. Bauer, R. Penzel, E. Schröck, A. Stenzinger, R. Schlenk, B. Brors, R. Russell, H. Glimm, M. Schlesner, S. Fröhling   +38 more
semanticscholar   +1 more source

A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12

Disease Models & Mechanisms, 2014
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither ...
Alexa Burger, Aleksandr Vasilyev, Ritu Tomar, Martin K. Selig, G. Petur Nielsen, Randall T. Peterson, Iain A. Drummond, Daniel A. Haber   +7 more
doaj   +1 more source

Thoracic chordoma [PDF]

Arquivos de Neuro-Psiquiatria, 2008
Rita, Delgado, Antonio de Pádua Furquim, Bonatelli, João Norberto, Stávale   +2 more
openaire   +2 more sources

Sellar chondroid chordoma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To investigate the clinical and pathological characteristics of sellar chondroid chordoma and discuss differential diagnosis of sellar chondroid chordoma with literature review.
Xia LI, Qing LI, Ying-mei WANG, Li-ying ZHANG, Yu GU   +4 more
doaj  

SACRAL CHORDOMA [PDF]

Medical Journal Armed Forces India, 2000
K J, Philipose, G, Ramdas, Y V, Suri, P, Takkar, A K, Malviya   +4 more
openaire   +2 more sources

Thoracic Chordoma [PDF]

Thorax, 1951
G G, CROWE, P B L, MULDOON
openaire   +2 more sources

SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc

BMC Cancer
Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT)5 plays pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found.
Minghui Jiang, Zheng Huang, Li Chen, Ting Deng, Junpeng Liu, Yue Wu   +5 more
doaj   +1 more source

Chordoma [PDF]

Proceedings of the Royal Society of Medicine, 1959
openaire   +2 more sources