Results 81 to 90 of about 16,071 (223)

N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis

Clinical and Translational Medicine
Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement in ...
Hanwen Li, Yingchuang Tang, Xingbang Ruan, Junxin Zhang, Hao Liu, Shiyu Yu, Hao Chen, Huilin Yang, Kai Zhang, Kangwu Chen   +9 more
doaj   +1 more source

Clinicopathological significance of p16, cyclin D1, Rb and MIB-1 levels in skull base chordoma and chondrosarcoma

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2015
Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb) and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these ...
Jun-qi Liu, Qiu-hang Zhang, Zhen-lin Wang   +2 more
doaj   +1 more source

Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death

Cancer Research, 2020
Pharmacologic inhibition of H3K27-demethylases in human chordoma cells promotes epigenetic silencing of oncogenic TBXT, alters gene networks critical to survival, and represents a potential novel therapy. Expression of the transcription factor brachyury (
Lucia Cottone, Adam P. Cribbs, Garima Khandelwal, G. Wells, Lorena Ligammari, M. Philpott, A. Tumber, P. Lombard, E. Hookway, T. Szommer, C. Johansson, P. Brennan, N. Pillay, Richard G. Jenner, U. Oppermann, A. Flanagan   +15 more
semanticscholar   +1 more source

Chordoma.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
The history, origin, pathology, diagnosis, treatment and prognosis of chordoma involving the axial skeleton are reviewed, and the clinical histories of 3 cases of chordoma are given, noting some remarkable features, along with one case misdiagnosed as chordoma on the radiological appearance of the sacrum and treated as such, which later proved to be a ...
Fichardt, T., de Villiers, P.C.
openaire   +3 more sources

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT

Cancer Cell International, 2019
Background Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in certain human tumors. However, the detailed biological function of TRIM11 in chordoma is still unclear.
Bin Wang, Gang Wang, Qingfeng Wang, Ziqiang Zhu, Yunqing Wang, Kangwu Chen, Huilin Yang   +6 more
doaj   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 778-787, August 2026.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology
Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of the body, grows slowly but often severely invades surrounding tissues and bones.
Yujia Chen, Hongwei Zhang
doaj   +1 more source

Olfactory‐Related Quality of Life After Endoscopic Transsphenoidal Surgery

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
The QOD‐LQ, QOD‐VAS, and the “decreased sense of smell” item of the SNOT‐22, reflecting olfactory‐related quality of life (QOL) and subjective olfactory dysfunction, significantly deteriorated after EETSA in a substantial proportion of patients, even though psychophysical olfactory function was preserved.
Yeong Ju Lee, Jeong Heon Kim, Chang‐Ki Hong, Young‐Hoon Kim, Ji Heui Kim   +4 more
wiley   +1 more source

Challenging the giant: A case report on a huge sacrococcygeal chordoma and its radiological insights

Radiology Case Reports
Sacral chordoma is a rare osseous tumor of malignant origin. Remnants of the notochord in the region of sacrum and coccyx is said to be the origin of these tumors.
Sakshi Dudhe, MBBS, Devyansh Nimodia, MBBS, Gaurav V. Mishra, MD, Pratapsingh H. Parihar, MD, Paritosh Bhangale, MBBS, Anjali Kumari, MBBS, Rishitha Kotla, MBBS   +6 more
doaj   +1 more source