Results 91 to 100 of about 16,071 (223)
Medical Physics, Volume 53, Issue 8, August 2026.Abstract Background In skull‐base proton therapy (PT), severe toxicity outcomes such as temporal lobe necrosis (TLN) may be associated with inadequate management of the actual radiobiological effectiveness (RBE) of proton beams. Combining dose‐averaged linear energy transfer (LETd) and dose may be crucial in treatment plan optimization and evaluation ...
Giulia Fontana +9 more
wiley +1 more source
Synergistic drug combinations and machine learning for drug repurposing in chordoma
Scientific Reports, 2020 Chordoma is a devastating rare cancer that affects one in a million people. With a mean-survival of just 6 years and no approved medicines, the primary treatments are surgery and radiation.
E. Anderson +9 more
semanticscholar +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.Abstract Thyroid transcription factor‐1 (TTF‐1) is a widely used immunohistochemical marker for tumors of thyroid and pulmonary origin; however, its expression profile and diagnostic relevance in primary central nervous system (CNS) tumors remain incompletely characterized, particularly following the revisions in the 2021 WHO Classification of CNS ...
Lu Xu +8 more
wiley +1 more source
Journal of the Belgian Society of Radiology, 2013 A 38-year-old man was admitted to our hospital for deep sacral pain. There was no significant medical history. Physical examination revealed pressure pain of the right sacroiliac joint. MRI showed a midline mass in the sacrum (arrows), isointense on T1- weighted MR images and hyperintense on T2-weighted MR images (Fig.
Behaeghe, M +3 more
openaire +5 more sources
HeliyonBackground: This study aimed to develop and validate nomograms to predict overall survival (OS) for pelvic Ewing's sarcoma (EWS) and chordoma, identify prognostic factors, and compare outcomes between the two conditions.
Wanyun Tang +4 more
doaj +1 more source
Imaging Findings of a Nonenhancing Intradural Paramedian Chordoma Mimicking an Epidermoid Cyst
대한영상의학회지, 2018 Intracranial chordoma is a rare tumor, originating from embryonic remnants of the primitive notochord. It typically appears as an enhancing extradural midline tumor with bone involvement.
Min Jeong Kim, Yae Won Park, Soo Mee Lim
doaj +1 more source
European spine journal, 2018 Background and aimsThe aim of this systematic review is to describe the epidemiology of chordoma and to provide a clear overview of clinical prognostic factors predicting progression-free and overall survival.MethodsFour databases of medical literature ...
S. Bakker +7 more
semanticscholar +1 more source
RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
Advanced ScienceChordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive, leading to a lack of effective therapeutic targets and drug sensitivity ...
Jianxuan Gao +15 more
doaj +1 more source
The driver landscape of sporadic chordoma
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
doaj +1 more source