Results 71 to 80 of about 16,071 (223)

Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma

The Journal of Pathology: Clinical Research, 2020
The expression of p16/CDKN2A, the second most commonly inactivated tumour suppressor gene in cancer, is lost in the majority of chordomas. However, the mechanism(s) leading to its inactivation and contribution to disease progression have only been ...
Lucia Cottone, Nadia Eden, Inga Usher, P. Lombard, H. Ye, Lorena Ligammari, D. Lindsay, S. Brandner, J. Pižem, N. Pillay, R. Tirabosco, F. Amary, A. Flanagan   +12 more
semanticscholar   +1 more source

Application of Three‐Dimensionally Printed Surgical Guides in Precise Sacral Tumor Excision and Defect Reconstruction

Orthopaedic Surgery, EarlyView.
Patient‐specific 3D‐printed guiding templates significantly improve surgical precision and efficiency in complex sacral tumor resection and reconstruction compared to conventional freehand techniques. This computer‐assisted workflow reduces operative time, intraoperative blood loss, and fluoroscopy frequency, providing a safer, highly reproducible ...
Yansong Liu, Yinghua He, Huanwen Ding, Hu Chen, Zhongbiao Liang, Ningling Xie, Renxuan Tu, Qiang Tu   +7 more
wiley   +1 more source

Reverse Septal Flap Necrosis in Endoscopic Skull Base Reconstruction

International Forum of Allergy &Rhinology, EarlyView.
Nana‐Hawwa Abdul‐Rahman, Aileen Cui, Garret Choby, Eric W. Wang, Georgios A. Zenonos, Paul A. Gardner, Carl H. Snyderman   +6 more
wiley   +1 more source

Systematic Review of AI‐Driven Applications for Screening Nasopharyngeal Carcinoma Using MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 593-615, September 2026.
ABSTRACT Background Nasopharyngeal carcinoma (NPC) can be detected early on MRI, but adoption for screening is limited by a shortage of experienced specialists. MRI artificial intelligence (AI) algorithms for diagnosing NPC in the literature may address this, but most studies focus on routine clinical care, and their applicability in screening requires
Lun M. Wong, Ho Sang Leung, Zuyao Yang, Yip Man Tsang, Yuet Ting Chan, Tiffany Y. So, Ann D. King, Qi Yong H. Ai   +7 more
wiley   +1 more source

Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis

The Laryngoscope, Volume 136, Issue 9, Page 3718-3731, September 2026.
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua, Yong Hoe Chan, Woei Shyang Loh, De Yun Wang   +3 more
wiley   +1 more source

Function and regulation of miR-186-5p, miR-125b-5p and miR-1260a in chordoma

BMC Cancer, 2023
Background The function and regulation of miRNAs in progression of chordoma were unclear. Methods Five miRNAs were identified by the machine learning method from the miRNA expression array. CCk-8 assay, EDU assay, wound healing migration assay, and trans-
Xulei Huo, Ke Wang, Bohan Yao, Lairong Song, Zirun Li, Wenyan He, Yiming Li, Junpeng Ma, Liang Wang, Zhen Wu   +9 more
doaj   +1 more source

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group

Annals of Oncology, 2017
Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many ...
S. Stacchiotti, A. Gronchi, P. Fossati, Toru Akiyama, C. Alapetite, Michael Baumann, J. Blay, S. Bolle, S. Boriani, Paolo Bruzzi, Rodolfo Capanna, Augusto Caraceni, R. Casadei, Vittoria Colia, Jürgen Debus, Thomas F. DeLaney, A. Desai, P. Dileo, S. Dijkstra, Francesco Doglietto, A. M. Flanagan, A. M. Flanagan, S. Froelich, P. Gardner, H. Gelderblom, Z. Gokaslan, R. Haas, C. Heery, N. Hindi, P. Hohenberger, F. J. Hornicek, R. Imai, L. Jeys, R. Jones, B. Kasper, Akira Kawai, M. Krengli, A. Leithner, I. Logowska, J. Broto, D. Mazzatenta, C. Morosi, Piero Nicolai, O. Norum, Shreyaskumar R. Patel, N. Penel, P. Picci, Silvana Pilotti, S. Radaelli, F. Ricchini, Piotr Rutkowski, S. Scheipl, C. Sen, E. Tamborini, K. Thornton, Beate Timmermann, V. Torri, P-U Tunn, M. Uhl, Y. Yamada, Damien C. Weber, D. Vanel, P. Varga, C. Vleggeert-Lankamp, P. G. Casali, J. Sommer   +65 more
semanticscholar   +1 more source

Mesenchymal Chondrosarcoma Presenting as Atypical Brown–Sequard Syndrome

Annals of the Child Neurology Society, EarlyView.
Naman D. Shah, Adam Z. Kalawi, Rachel Pearson, Ali Nael, John R. Crawford   +4 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Develop a novel non‐coplanar trajectory optimization algorithm for an efficient 4pi spot‐scanning proton Arc (SPArc‐4pi) treatment delivery

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background The degree of freedom has been recognized as a key factor in particle beam therapy, such as improving the dose conformity and linear energy transfer distributions. Therefore, proton arc therapy has drawn significant interest in the Society of Radiation Oncology as a potentially efficient and optimal treatment option for cancer ...
Xiaoda Cong, Shupeng Chen, Peilin Liu, Peng Chen, Xiangkun Xu, Xiaoqiang Li, Peter Chen, Prakash Chinnaiyan, Xuanfeng Ding   +8 more
wiley   +1 more source