Results 51 to 60 of about 16,071 (223)

XIST sponges miR-320d to promote chordoma progression by regulating ARF6

Journal of Bone Oncology, 2022
Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in ...
Yonggang Wang, Zhouzhou Tang, Weichun Guo   +2 more
doaj   +1 more source

Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial Chordoma: A clinicopathological and molecular analysis

Genes, Chromosomes and Cancer, 2021
Extra‐axial chordoma is a rare neoplasm of extra‐axial skeleton and soft tissue that shares identical histomorphologic and immunophenotypic features with midline chordoma. While genetic changes in conventional chordoma have been well‐studied, the genomic
Xiaoyun Wen, Robert Cimera, R. Aryeequaye, Mohanty Abhinta, E. Athanasian, J. Healey, N. Fabbri, P. Boland, Yanming Zhang, M. Hameed   +9 more
semanticscholar   +1 more source

Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells

Cancer Research Communications, 2021
Chordoma is a rare tumor derived from notochord remnants that has a propensity to recur and metastasize despite conventional multimodal treatment. Cancer stem cells (CSC) are implicated in chordoma’s resistant and recurrent behavior; thus strategies that
A. Hoke, M. Padget, Kellsye P. Fabian, Anjali Nandal, G. Gallia, Marijo Bilusic, P. Soon-Shiong, J. Hodge, N. London   +8 more
semanticscholar   +1 more source

Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma

Photodiagnosis and Photodynamic Therapy
Background: Chordoma is a rare congenital low-grade malignant tumor characterized by infiltrative growth. It often tends to compress important intracranial nerves and blood vessels, making its surgical treatment extremely difficult. Besides, the efficacy
Lei Li, Kai-lun Wei, Ming-song Liu, Qi-lin Wang, Tong-fei Zeng, Rui-zhe Chen, Xue-wei Xia, Hong-tian Zhang   +7 more
doaj   +1 more source

Establishment and genomic characterization of the new chordoma cell line Chor-IN-1

Scientific Reports, 2017
Chordomas are rare, slowly growing tumors with high medical need, arising in the axial skeleton from notochord remnants. The transcription factor “brachyury” represents a distinctive molecular marker and a key oncogenic driver of chordomas.
Roberta Bosotti, Paola Magnaghi, Sebastiano Di Bella, Liviana Cozzi, Carlo Cusi, Fabio Bozzi, Nicola Beltrami, Giovanni Carapezza, Dario Ballinari, Nadia Amboldi, Rosita Lupi, Alessio Somaschini, Laura Raddrizzani, Barbara Salom, Arturo Galvani, Silvia Stacchiotti, Elena Tamborini, Antonella Isacchi   +17 more
doaj   +1 more source

Developmental Morphometry of the Paranasal Sinuses in Subjects Aged 1–25 Years: A Computed Tomography Study

Clinical Anatomy, EarlyView.
ABSTRACT The present study aimed to evaluate the developmental morphometry of the paranasal sinuses using computed tomography (CT) in subjects aged 1–25 years and to characterize age‐related changes in sinus dimensions, volume, and surface area throughout childhood, adolescence, and young adulthood.
Ceyda Şevval Çetin, Aslıhan Artaş, Ali Atadağ, Ömer Faruk Cihan, Orhan Beger   +4 more
wiley   +1 more source

Potential molecular mechanism in self-renewal is associated with miRNA dysregulation in sacral chordoma – A next-generation RNA sequencing study

Heliyon, 2022
Background: Chordoma, the most frequent malignant primary spinal neoplasm, characterized by a high rate of recurrence, is an orphan disease where the clarification of the molecular oncogenesis would be crucial to developing new, effective therapies ...
Arpad Bozsodi, Beata Scholtz, Gergo Papp, Zoltan Sapi, Adam Biczo, Peter Pal Varga, Aron Lazary   +6 more
doaj   +1 more source

Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells

International Journal of Oncology, 2021
Chordoma is a rare low-grade tumor of the axial skeleton. Over previous decades, a range of targeted drugs have been used for treating chordoma, with more specific and effective therapies under investigation.
Jinxing Yang, Han-Ni Huang, D. Xiao, Yang Duan, Yanfang Zheng, Zhong Chen   +5 more
semanticscholar   +1 more source

Long Non-Coding RNA KCNQ1OT1 Promotes Multidrug Resistance in Chordoma by Functioning as a Molecular Sponge of miR-27b-3p and Subsequently Increasing ATF2 Expression

Cancer Management and Research, 2020
Lei Li, Guohua Lv, Bing Wang, Hong Ma Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaCorrespondence: Hong Ma Tel +86 731-85295124Email spinema@csu.edu ...
Li L, Lv G, Wang B, Ma H
doaj  

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source