Results 51 to 60 of about 7,766 (184)

Function and regulation of miR-186-5p, miR-125b-5p and miR-1260a in chordoma

BMC Cancer, 2023
Background The function and regulation of miRNAs in progression of chordoma were unclear. Methods Five miRNAs were identified by the machine learning method from the miRNA expression array. CCk-8 assay, EDU assay, wound healing migration assay, and trans-
Xulei Huo, Ke Wang, Bohan Yao, Lairong Song, Zirun Li, Wenyan He, Yiming Li, Junpeng Ma, Liang Wang, Zhen Wu   +9 more
doaj   +1 more source

Evolving role of proton therapy in contemporary oncology

Cancer, Volume 132, Issue 20, 15 October 2026.
Abstract Proton therapy offers a distinct physical advantage over photon radiotherapy through the Bragg peak dose concentration in target with both lower integral dose and finite path length, and sharper penumbra as compared to photons, collectively reducing radiation exposure to surrounding normal tissues and potentially improving the therapeutic ...
Emily S. Lebow, Helen A. Shih
wiley   +1 more source

Longitudinal trends in Gamma Knife radiosurgery utilization across multiple technological generations: A Single‐Institution Observational Study

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Gamma Knife radiosurgery (GKRS) has been a foundational modality for the treatment of intracranial diseases for several decades, with successive platform generations introducing substantial technological advancements. Improvements in source configuration, patient positioning systems, imaging guidance, and immobilization techniques ...
Daniel El Basha, Eric Filiput, Austen Curcuru, Sven Ferguson, Sreekrishna Murty Goddu, Nels Knutson, Hugh Lee, Timothy Mitchell, Seungjong Oh, Joshua L. Dowling, Jiayi Huang, Taeho Kim   +11 more
wiley   +1 more source

Understanding the Symptom Burden of Complex Skull Base Tumors From the Patient's Perspective

Head &Neck, Volume 48, Issue 10, Page 2720-2732, October 2026.
ABSTRACT Background Symptom burden of skull base tumor (SBT) patients, especially those undergoing multimodality treatment, is poorly understood. We aim to understand symptom burden in this patient group using the core module the MD Anderson Symptom Inventory (MDASI).
Shirley Y. Su, Matheus Sewastjanow‐Silva, Jack Phan, Marc‐Elie Nader, Shaan M. Raza, Franco DeMonte, Paul W. Gidley, Ehab Y. Hanna, Loretta A. Williams   +8 more
wiley   +1 more source

N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis

Clinical and Translational Medicine
Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement in ...
Hanwen Li, Yingchuang Tang, Xingbang Ruan, Junxin Zhang, Hao Liu, Shiyu Yu, Hao Chen, Huilin Yang, Kai Zhang, Kangwu Chen   +9 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Clinicopathological significance of p16, cyclin D1, Rb and MIB-1 levels in skull base chordoma and chondrosarcoma

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2015
Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb) and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these ...
Jun-qi Liu, Qiu-hang Zhang, Zhen-lin Wang   +2 more
doaj   +1 more source

Challenging the giant: A case report on a huge sacrococcygeal chordoma and its radiological insights

Radiology Case Reports
Sacral chordoma is a rare osseous tumor of malignant origin. Remnants of the notochord in the region of sacrum and coccyx is said to be the origin of these tumors.
Sakshi Dudhe, MBBS, Devyansh Nimodia, MBBS, Gaurav V. Mishra, MD, Pratapsingh H. Parihar, MD, Paritosh Bhangale, MBBS, Anjali Kumari, MBBS, Rishitha Kotla, MBBS   +6 more
doaj   +1 more source

Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT

Cancer Cell International, 2019
Background Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in certain human tumors. However, the detailed biological function of TRIM11 in chordoma is still unclear.
Bin Wang, Gang Wang, Qingfeng Wang, Ziqiang Zhu, Yunqing Wang, Kangwu Chen, Huilin Yang   +6 more
doaj   +1 more source

Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology
Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of the body, grows slowly but often severely invades surrounding tissues and bones.
Yujia Chen, Hongwei Zhang
doaj   +1 more source