Results 31 to 40 of about 16,071 (223)
Frontiers in Pharmacology, 2021 Chordoma is a relatively rare malignant bone tumor with high local recurrence. To date, the mechanism remains unclear. lncRNAs play a pivotal role in tumorigenesis by acting as competitive endogenous RNAs of microRNAs.
Kai Zhang +7 more
doaj +1 more source
Research hotspots and trends of chordoma: A bibliometric analysis
Frontiers in Oncology, 2022 BackgroundChordoma is a type of mesenchymal malignancy with a high recurrence rate and poor prognosis. Due to its rarity, the tumorigenic mechanism and optimal therapeutic strategy are not well known.MethodsAll relevant articles of chordoma research from
Jianxuan Gao +6 more
doaj +1 more source
Bibliometric analysis of the global research trends and hotspots in chordoma from 2000 to 2020
PLoS ONE, 2022 Introduction Chordoma is formed from embryonic residues or ectopic chordae and locally aggressive or malignant tumors. We visually analyzed the research tendency and hotspot of chordoma.
Cuicui Chang +4 more
doaj +3 more sources
Immunotherapy as a Promising Option for the Treatment of Advanced Chordoma: A Systemic Review
Cancers, 2022 Simple Summary Chordoma is a rare orthopedic tumor that is mainly treated with surgery and radiotherapy. Due to the disease characteristics of chordoma, it is difficult to remove completely and easily recur.
Xiang Wang +5 more
semanticscholar +1 more source
The Oncologist, 2021 Background Brachyury is a transcription factor overexpressed in chordoma and is associated with chemotherapy resistance and epithelial‐to‐mesenchymal transition. GI‐6301 is a recombinant, heat‐killed Saccharomyces cerevisiae yeast‐based vaccine targeting
P. DeMaria +13 more
semanticscholar +1 more source
Research Advances in Molecular Regulatory Mechanism of Chordoma
Zhongliu Fangzhi Yanjiu, 2019 Chordoma is a rare primary malignant bone tumor derived from notochord remnants. Due to its strong local invasiveness and chemotherapy resistance, chordoma has a high local recurrence rate and poor prognosis.
LIANG Chen, YANG Chenlong, LIU Xiaoguang
doaj +1 more source
B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma
Frontiers in Oncology, 2021 Objective chordomas are rare bone tumors with few therapeutic options. Skull base and sacrum are the two most common origin sites. Immunotherapies are emerging as the most promising approaches to fight various cancers.
Cheng Long +6 more
semanticscholar +1 more source
Technology in Cancer Research & Treatment, 2021 Background: Chordoma is a rare malignant bone tumor, and the survival prediction for patients with chordoma is difficult. The objective of this study was to construct and validate a nomogram for predicting cancer-specific survival (CSS) in patients with ...
Zhangheng Huang +3 more
doaj +1 more source
DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma.
Neuro-Oncology, 2021 BACKGROUND Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that are
J. Zuccato +19 more
semanticscholar +1 more source