Results 11 to 20 of about 16,071 (223)

From Histology to Multi-Omics: Review of Chordoma Classification and Its Clinical Implications [PDF]

Cells
Chordoma is a rare malignant neoplasm of the axial skeleton, arising from notochordal remnants. No approved systemic therapies exist, and the 10-year overall survival is below 60%.
Szymon Piotr Baluszek, Paulina Kober, Mateusz Bujko   +2 more
doaj   +2 more sources

CHI3L1 Expression in Chordoma: Implications for Immunotherapeutic Intervention [PDF]

Cells
Chordomas are rare, highly morbid tumors arising from notochordal progenitor cells along the spinal axis, associated with severe neurological complications and high recurrence rates.
Beatrice Campilan, Christian Godinez, Jonathan Arditi, Jessica Ding, Kaylee Gallagher, Andrew Fogarty, Christian Schroeder, Madison J. Michles, Weston de Lomba, Joselynn Wallace, John Santiago, Michael Punsoni, Suchitra Kamle, Jack A. Elias, Christine Lee, Ziya L. Gokaslan, Margot Martinez-Moreno, Patricia L. Zadnik Sullivan   +17 more
doaj   +2 more sources

Human eosinophils exert antitumorigenic effects on chordoma [PDF]

Chinese Neurosurgical Journal
Background Chordoma is a devastating rare tumor with a poor prognosis, limited therapeutic options and a high recurrence rate. The exploration of novel therapeutic targets has important clinical significance in chordoma diagnosis, treatment, and outcome ...
Wang Ying, Li Peng, Bai Jingqiao, Xu Lingzhi, Ren Yuan, Liu Pinan, Wang Bo   +6 more
doaj   +2 more sources

Chordoma: A Comprehensive Systematic Review of Clinical Trials

Cancers, 2023
Simple Summary Surgery is the primary treatment for chordoma. However, residual or recurrent chordoma presents a significant problem for clinicians. The aim of this work is to highlight the current treatment landscape for chordoma, with a particular ...
Sonja Chen, Ruben Ulloa, Justin M Soffer, Roberto J. Alcazar-Felix, C. Snyderman, Paul A. Gardner, Vijay A. Patel, Sean P. Polster   +7 more
semanticscholar   +1 more source

Transcriptional profiling supports the notochordal origin of chordoma and its dependence on a TGFΒ1-TBXT network.

American Journal of Pathology, 2023
Chordoma is a rare malignant tumor demonstrating notochordal differentiation. It is dependent on Brachyury (TBXT), a hallmark notochordal gene and transcription factor, and shares histological features and the same anatomical location as the notochord ...
Stefan C. Halvorsen, Yair Benita, Megan Hopton, Brooke K. Hoppe, H. Gunnlaugsson, Parimal Korgaonkar, C. Vanderburg, G. Nielsen, N. Trepanowski, Jaime H. Cheah, M. Frosch, J. Schwab, A. Rosenberg, F. Hornicek, Slim Sassi   +14 more
semanticscholar   +1 more source

The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies

Frontiers in Immunology, 2023
Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy.
Jiuhui Xu, Qianyu Shi, Boyang Wang, T. Ji, Wei Guo, T. Ren, Xiaodong Tang   +6 more
semanticscholar   +1 more source

Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival

Nature Communications, 2021
Chordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas and identify PBRM1, a SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as a significantly ...
J. Bai, Jianxin Shi, Chuzhong Li, Shuai Wang, Tongwu Zhang, X. Hua, B. Zhu, H. Koka, Ho-Hsiang Wu, Lei Song, Difei Wang, Mingyi Wang, Weiyin Zhou, B. Ballew, B. Zhu, B. Hicks, L. Mirabello, D. Parry, Y. Zhai, Mingxuan Li, Jiang Du, Junmei Wang, Shuheng Zhang, Qian Liu, P. Zhao, S. Gui, A. Goldstein, Yazhuo Zhang, Xiaohong R. Yang   +28 more
semanticscholar   +1 more source

Activity of pemetrexed in pre-clinical chordoma models and humans

Scientific Reports, 2023
Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists.
Santosh Kesari, Feng Wang, Tiffany Juarez, Shashaanka Ashili, C. Pawan K. Patro, Jose Carrillo, Minhdan Nguyen, Judy Truong, Joan Levy, Josh Sommer, Daniel M. Freed, Joanne Xiu, Yuki Takasumi, Eric Bouffet, Jaya M. Gill   +14 more
doaj   +1 more source

CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma [PDF]

Scientific Reports
CD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacterized. This study aimed
Yuhang Wang, Jiuhui Xu, Shouyan Deng, Kunkun Sun, Yaqi Wang, Tingting Ren, Xiaodong Tang, Jie Xu, Lu Xie   +8 more
doaj   +2 more sources

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Journal of Craniovertebral Junction and Spine, 2020
Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through ...
Mohammadreza Chehrassan, Adel Ebrahimpour, Mehrdad Sadighi, Mehdi Azizmohammad Looha, Saber Barazandeh Rad, Mohammad Esmaeil Akbari   +5 more
doaj   +1 more source