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Expression of
Journal of Experimental & Clinical Cancer Research, 2010 Background Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy and radiotherapy.
Ma Baoan +8 more
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A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. [PDF]
PLoS ONE, 2013 Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to ...
Matteo M Trucco +15 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2015 Paediatric chordomas are rare malignant tumours arising from primitive notochordal remnants with a high rate of recurrence. Only 5 % of them occur in the first two decades such less than 300 paediatric cases have been reported so far in the literature. In children, the average age at diagnosis is 10 years with a male-to-female ratio closed to 1. On the
Beccaria, Kévin +3 more
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Oronasopharyngeal chordomas [PDF]
Acta Neurochirurgica, 2009 Chordomas are rare tumors derived from notochordal remnants. The authors report on a series of three cases of primary familial oronasopharyngeal chordomas treated at our institution.A retrospective chart review was completed of the three cases of primary familial oronasopharyngeal chordoma treated at the University of Utah.All three patients (100 ...
Jeroen R, Coppens +4 more
openaire +2 more sources
MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET. [PDF]
PLoS ONE, 2014 Chordomas are rare malignant tumors that originate from the notochord remnants and occur in the skull base, spine and sacrum. Due to a very limited understanding of the molecular pathogenesis of chordoma, there are no adjuvant and molecular therapies ...
Ying Zhang +3 more
doaj +1 more source
XIST sponges miR-320d to promote chordoma progression by regulating ARF6
Journal of Bone Oncology, 2022 Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in ...
Yonggang Wang +2 more
doaj +1 more source
Recurrent Metastatic Chordoma to the Liver: A Case Report and Review of the Literature
Current Oncology, 2022 Chordoma is a rare malignant neoplasm derived from notochordal tissue that primarily affects the axial skeleton. Almost 40% of patients have non-cranial chordoma metastases.
Thomas E. Dickerson +8 more
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Clinical Anatomy, EarlyView.ABSTRACT The present study aimed to evaluate the developmental morphometry of the paranasal sinuses using computed tomography (CT) in subjects aged 1–25 years and to characterize age‐related changes in sinus dimensions, volume, and surface area throughout childhood, adolescence, and young adulthood.
Ceyda Şevval Çetin +4 more
wiley +1 more source
Photodiagnosis and Photodynamic TherapyBackground: Chordoma is a rare congenital low-grade malignant tumor characterized by infiltrative growth. It often tends to compress important intracranial nerves and blood vessels, making its surgical treatment extremely difficult. Besides, the efficacy
Lei Li +7 more
doaj +1 more source