Results 1 to 10 of about 16,071 (223)
Chordoma: A Review and Differential Diagnosis. [PDF]
Archives of Pathology & Laboratory Medicine, 2021 CONTEXT.— Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton.
V. Ulici, J. Hart
semanticscholar +3 more sources
Journal for ImmunoTherapy of Cancer, 2023 Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma.
Wei Wang +14 more
doaj +2 more sources
Mapping the landscape of genetic dependencies in chordoma
Nature Communications, 2023 Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.
Tanaz Sharifnia +15 more
doaj +2 more sources
Chordoma—Current Understanding and Modern Treatment Paradigms
Journal of Clinical Medicine, 2021 Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum which behaves malignantly and confers a poor prognosis despite indolent growth patterns.
Adetokunbo Oyelese +2 more
exaly +2 more sources
DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5
Cell Death and Disease, 2021 Chordoma is a rare bone malignancy with a high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) is implicated in a variety of malignancies, its relationship with chordoma is unclear.
Liang Wang +8 more
doaj +2 more sources
Immunotherapy for Chordoma and Chondrosarcoma: Current Evidence
Cancers, 2021 Simple Summary Chordomas and chondrosarcomas are rare tumors that can occur within the skull base and spinal column and are often resistant to chemotherapy and radiation.
Tomáš Garzón-Muvdi +2 more
exaly +2 more sources
Chordoma: Genetics and Contemporary Management
International Journal of Molecular SciencesChordomas, arising from notochord remnants, are rare neoplasms with aggressive growth patterns despite their histologically low-grade nature. This review explores their embryological origins, molecular markers like brachyury, and genetic alterations ...
Panayiotis Pelargos +2 more
exaly +2 more sources
European Journal of Surgical Oncology, 2020 OBJECTIVE Aim of the manuscript is to discuss how to improve margins in sacral chordoma. BACKGROUND Chordoma is a rare neoplasm, arising in half cases from the sacrum, with reported local failure in >50% after surgery.
Giovanni Grignani +2 more
exaly +2 more sources
Clinical and Translational Medicine, 2023 Background Skull base chordoma is a rare and aggressive tumour of the bone that has a high likelihood of recurrence. The fundamental differences in single cells between primary and recurrent lesions remain poorly understood, impeding development of ...
Xulei Huo +9 more
semanticscholar +1 more source
Cancers, 2023 Simple Summary Chordomas are rare tumors of the embryologic spinal cord remnant. They are locally aggressive and typically managed with surgery in combination with radiation therapy.
K. Redmond +14 more
semanticscholar +1 more source