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From Histology to Multi-Omics: Review of Chordoma Classification and Its Clinical Implications [PDF]
CellsChordoma is a rare malignant neoplasm of the axial skeleton, arising from notochordal remnants. No approved systemic therapies exist, and the 10-year overall survival is below 60%.
Szymon Piotr Baluszek +2 more
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CHI3L1 Expression in Chordoma: Implications for Immunotherapeutic Intervention [PDF]
CellsChordomas are rare, highly morbid tumors arising from notochordal progenitor cells along the spinal axis, associated with severe neurological complications and high recurrence rates.
Beatrice Campilan +17 more
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Archives of Pathology & Laboratory Medicine, 2021 Context.— Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton.
Veronica, Ulici, Jesse, Hart
openaire +2 more sources
Mapping the landscape of genetic dependencies in chordoma
Nature Communications, 2023 Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.
Tanaz Sharifnia +15 more
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Journal for ImmunoTherapy of Cancer, 2023 Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma.
Wei Wang +14 more
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Activity of pemetrexed in pre-clinical chordoma models and humans
Scientific Reports, 2023 Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists.
Santosh Kesari +14 more
doaj +1 more source
PALB2 as a factor to predict the prognosis of patients with skull base chordoma
Frontiers in Oncology, 2022 ObjectiveThis study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.
Yujia Xiong +8 more
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Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study
Journal of Craniovertebral Junction and Spine, 2020 Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through ...
Mohammadreza Chehrassan +5 more
doaj +1 more source
DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5
Cell Death and Disease, 2021 Chordoma is a rare bone malignancy with a high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) is implicated in a variety of malignancies, its relationship with chordoma is unclear.
Liang Wang +8 more
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Frontiers in Oncology, 2020 PurposeChordomas are rare, slow-growing sarcomas without any accepted prognostic biomarkers. Owing to their proximity to critical neurovascular structures, discovering predictive biomarkers in chordoma has been a significant research effort because it ...
Ran Wei +7 more
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