Results 61 to 70 of about 16,071 (223)

Fluid-fluid level as an atypical radiological sign of clival chordoma

Radiology Case Reports, 2021
Chordoma is a rare and aggressive intracranial bone tumor that is difficult to diagnose and resect with a peak incident between the ages of 20–40 years old and high recurrence rate when not completely resected.
Fahad B. Albadr, Mishari F. Alsalem, Faisal S. Alzahrani   +2 more
doaj   +1 more source

Molecular Targeted Therapy in the Treatment of Chordoma: A Systematic Review

Frontiers in Oncology, 2019
Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base. Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular targeted therapy (MTT) is an option for advanced chordoma, but its therapeutic
T. Meng, Jiali Jin, Cong Jiang, Runzhi Huang, Huabin Yin, D. Song, Liming Cheng   +6 more
semanticscholar   +1 more source

Understanding the Symptom Burden of Complex Skull Base Tumors From the Patient's Perspective

Head &Neck, EarlyView.
ABSTRACT Background Symptom burden of skull base tumor (SBT) patients, especially those undergoing multimodality treatment, is poorly understood. We aim to understand symptom burden in this patient group using the core module the MD Anderson Symptom Inventory (MDASI).
Shirley Y. Su, Matheus Sewastjanow‐Silva, Jack Phan, Marc‐Elie Nader, Shaan M. Raza, Franco DeMonte, Paul W. Gidley, Ehab Y. Hanna, Loretta A. Williams   +8 more
wiley   +1 more source

Viability of Tumor Cells in Bone Dust: Implications for Oncologic Skull Base Surgery

Head &Neck, EarlyView.
ABSTRACT Background Head and neck tumors with skull base involvement may require drilling of tumor infiltrated bone. We hypothesize that bone dust generated during this process contains viable tumor cells that may seed the surgical field. Methods Tumors with gross bone invasion were drilled, and dust was collected for H&E, cell viability analysis, and ...
Kelly Bridgham, Hani Samarah, Emma De Ravin, Hannah Kenny, Eric Mastrolonardo, Annie Moroco, Suhao Han, Oliver Abinader, Ramkrishna Mitra, Alban Linnenbach, Gurston Nyquist, Christopher Farrell, Stacey Gargano, Andrew P. South, Adam Luginbuhl   +14 more
wiley   +1 more source

Low expression of H3K27me3 is associated with poor prognosis in conventional chordoma

Frontiers in Oncology, 2022
PurposeChordoma is a rare and locally invasive neoplasm, and the prognostic factors are limited. Deregulation of Histone 3 lysine 27 (H3K27) trimethylation (H3K27me3) is considered to be related with poor prognosis in some tumors.
Jie Wei, Jianfeng Wu, Zhiyong Yin, Xia Li, Yixiong Liu, Yingmei Wang, Zhe Wang, Chao Xu, Chao Xu, Linni Fan   +9 more
doaj   +1 more source

Perineal chordoma cutis, a rare localization for a rare pathology: a case report and consideration of the literature

PAMJ Clinical Medicine, 2020
The chordoma is a very rare notochordal tumor, the cutaneous localization (chordoma cutis) is even rarer and generally follows a local invasion of the integument even a metastasis. The clinical presentation is non-specific and the diagnosis is often late.
Chennoufi Mehdi, Mhanna Tarik, Irzi Mohamed, Jdaini Ahmed, Boukhannous Ibrahim, Barki Ali   +5 more
doaj   +1 more source

Bibliometric Insights in Advances of Chordoma: Global Trends and Research Development in the Last Decade

Orthopaedic Surgery, 2023
Chordoma is a rare tumor, but has a serious effect on the quality of life of patients. This study aims to assess the overall knowledge structure and trends in the development of chordoma research using a bibliometric analysis and visualization tool ...
Yu Xiao, Wenlong Yu, Jianhu Zheng, Lin Cheng, Xing Ding, Liang Qiao, Xuequn Wu, Junming Ma   +7 more
doaj   +1 more source

Applications and prospects of artificial intelligence and digital medicine in pediatric nasal skull base tumors

Pediatric Investigation, EarlyView.
Pediatric nasal skull base tumors present diagnostic and therapeutic challenges due to their deep location, nonspecific symptoms, and the narrow nasal cavity in children. Although artificial intelligence (AI) and digital medicine have advanced early diagnosis, multidisciplinary treatment, and prognosis, their application in these rare tumors remains ...
Xiuping Wu, Jing Wei, Chen Liu, Pengpeng Wang, Wentong Ge, Yang Han   +5 more
wiley   +1 more source

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

Disease Models & Mechanisms, 2019
The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants.
Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger   +8 more
doaj   +1 more source