PLoS ONE, 2020 Until recently the in utero environment of pregnant women was considered sterile. Recent high-sensitivity molecular techniques and high-throughput sequencing lead to some evidence for a low-biomass microbiome associated with the healthy placenta.
Rémi Gschwind +7 more
doaj +1 more source
Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. [PDF]
, 2019 Prenatal stem cell-based regenerative therapies have progressed substantially and have been demonstrated as effective treatment options for fetal diseases that were previously deemed untreatable. Due to immunoregulatory properties, self-renewal capacity,
Farmer, Diana L +7 more
core +1 more source
Evidence for HPV DNA in the placenta of women who resorted to elective abortion
BMC Pregnancy and Childbirth, 2021 Background It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the
Maria Teresa Bruno +4 more
doaj +1 more source
False negative NIPT results: Risk figures for chromosomes 13,18 and 21 based on chorionic villi results in 5967 cases and literature review [PDF]
, 2016 Non-invasive prenatal testing (NIPT) demonstrated a small chance for a false negative result. Since the "fetal" DNA in maternal blood originates from the cytotrophoblast of chorionic villi (CV), some false negative results will have a biological origin ...
Berg, C.D.F. (Cardi) van den +10 more
core +1 more source
Antioxidants, 2021 Preeclampsia, a hypertensive disorder occurring during pregnancy, is characterized by excessive oxidative stress and trophoblast dysfunction with dysregulation of soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) production ...
Isabelle Hernandez +7 more
doaj +1 more source
Retrospective study of trisomy 18 in chorionic villi with fluorescent in situ hybridization on archival direct preparations [PDF]
, 1995 Trisomy 18 in direct chorionic villus preparations needs further investigation since the chromosome abnormality may be confined to the placenta and may not represent the actual fetal karyotype.
Berg, C.D.F. (Cardi) van den +5 more
core +1 more source
Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]
, 2019 Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang +8 more
core +1 more source
An evaluation of cytogenetic diagnosis by chorionic villus sampling:reliability and implications [PDF]
, 1992 L-Aspartic acid-β-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylgluco-saminidase).
Breed, Antonius Simon Petrus Maria
core +5 more sources
Intra-uterine fetal demise caused by amniotic band syndrome after standard amniocentesis [PDF]
, 2000 The amniotic band syndrome represents a prime example of exogenous disruption of an otherwise normal feta I development. It may be a sequel of invasive diagnostic procedures such as amniocentesis or fetal blood sampling. A 38-year-old gravida II, para II
Bauerfeind, I. +4 more
core +1 more source
Triploidy--Observations in 154 Diandric Cases. [PDF]
PLoS ONE, 2015 Hydatidiform moles (HMs) are abnormal human pregnancies with vesicular chorionic villi, imposing two clinical challenges; miscarriage and a risk of gestational trophoblastic neoplasia (GTN).
Nanna Brink Scholz +7 more
doaj +1 more source