Results 51 to 60 of about 18,875 (235)

Designing Effective Multi-Target Drugs and Identifying Biomarkers in Recurrent Pregnancy Loss (RPL) Using In Vivo, In Vitro, and In Silico Approaches

Biomedicines, 2023
Recurrent pregnancy loss (RPL) occurs in approximately 5% of women. Despite an abundance of evidence, the molecular mechanism of RPL’s pathology remains unclear. Here, we report the protective role of polo-like kinase 1 (PLK1) during RPL.
Andrés Alexis Ramírez-Coronel, Amirabbas Rostami, Laith A. Younus, José Luis Arias Gonzáles, Methaq Hadi Lafta, Ali H. Amin, Mohammed Abdulkadhim Saadoon, Hayder Mahmood Salman, Abolfazl Bahrami, Rossa Feilei, Reza Akhavan-Sigari   +10 more
doaj   +1 more source

Increased incidence of cytogenetic abnormalities in chorionic villus samples from pregnancies established by in vitro fertilization and embryo transfer (IVF-ET) [PDF]

, 1995
We studied 201 pregnancies that were established by in vitro fertilization and embryo transfer (IVF–ET) and compared the frequency of cytogenetic abnormalities with that found in a large control population matched for indication group (advanced maternal ...
Berg, C.D.F. (Cardi) van den, Brandenburg, H. (Helen), Jahoda, M.G. (M.), Los, F.J., Ooijen, M. (M.) van, Pijpers, L. (Leendert), Stijnen, Th. (Theo), Van Opstal, A.R.M. (Diane), Veld, P.A. (Peter) in't   +8 more
core   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya. [PDF]

, 2019
BackgroundPreterm birth (PTB) is a major cause of infant morbidity and mortality in developing countries. Recent data suggest that in addition to Human Immunodeficiency Virus (HIV) infection, use of antiretroviral therapy (ART) increases the risk of PTB.
Cohen, Craig R, Fisher, Susan J, McMaster, Michael T, Obimbo, Moses M, Ogeng'o, Julius A, Ong'ech, John, Qureshi, Zahida, Zhou, Yan   +7 more
core  

Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B.
Átila V. V. Nobre, Pedro H. F. Silva, Marina C. G. Del‐Arco, Raquel F. Gerlach, Rene S. Oliezer, José E. Tanus‐Santos, Luciene C. Figueiredo, Janaina S. A. M. Evangelista, Flávia A. C. Furlaneto, Michel R. Messora, Sérgio Luiz Salvador   +10 more
wiley   +1 more source

Histological Appearance of Placental Solomonization in the Treatment of Twin–Twin Transfusion Syndrome

American Journal of Perinatology Reports, 2016
Background Placental laser equatorialization or “solomonization” during treatment for twin–twin transfusion syndrome (TTTS) is associated with improved pregnancy outcomes.
Stephen P. Emery, Lananh Nguyen, W. Tony Parks   +2 more
doaj   +1 more source

Construction and Evaluation of a Ballistic Gelatin‐Based Simulator for Transcervical Chorionic Villus Sampling

Journal of Ultrasound in Medicine, EarlyView.
Chorionic villus sampling (CVS) is a crucial prenatal diagnostic tool, but a declining number of procedures makes training a challenge. Here we describe a transcervical CVS simulator made from ballistic gelatin. Ninety‐three Maternal‐Fetal Medicine providers used the simulators during hands‐on workshops and completed surveys regarding their fidelity ...
Joshua F Nitsche, S Delaney, Peter Napolitano, Brian C Brost   +3 more
wiley   +1 more source

MORPHOMETRIC PARAMETERS OF PLACENTAL CHORIONIC VILLI IN LABOR AFTER 40 WEEKS

Неонатологія, хірургія та перинатальна медицина
The placenta is the main organ that ensures the vital activity of the fetus during pregnancy. Studying the morphometric characteristics of chorionic villi allows us to better understand the changes that occur in the placenta in late pregnancy.
О. Козар
doaj   +1 more source

Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation [PDF]

, 2006
An imprinting disorder has been believed to underlie the etiology of familial biparental hydatidiform moles (HMs) based on the abnormal methylation or expression of imprinted genes in molar tissues.
Coullin, Philippe, Djuric, Ugljesa, El Maarri, Osman, Hanash, Samir, Kuick, Rork, Lamb, Barbara, Oldenburg, Johannes, Seoud, Muheiddine, Slim, Rima   +8 more
core   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source